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Association between Val158Met COMT, TNF-alpha-857 C > T, TNFR1 36 A > G, IL-1 alpha 4845 G > T and IL-10-1082 A > G Polymorphisms and Risk of Early-Onset Preeclampsia and Its Complications
dc.creator | Krnjeta, Tijana | |
dc.creator | Mirković, Ljiljana | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Tomasević, Dragana | |
dc.creator | Lukić, Jelena | |
dc.creator | Topalov, Drina | |
dc.creator | Majkić-Singh, Nada | |
dc.date.accessioned | 2019-09-02T11:58:38Z | |
dc.date.available | 2019-09-02T11:58:38Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0042-8450 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2848 | |
dc.description.abstract | Background/Aim. Preeclampsia (PE) belongs to the group of hypertensive disorders in pregnancy with the global average incidence of 2.16%. It is considered as one of the leading causes of maternal and neonatal morbidity and mortality worldwide. The goal of this study was to assess the potential association between Val158Met catechol-o-methyltransferase (COMT), tumor necrosis factor-alpha (TNF-alpha) -857 C>T, tumor necrosis factor receptor 1 (TNFR1) 36 A>G, interleukin-1alpha (IL-1 alpha) 4845 G>T and interleukin-10 (IL-10) -1082 A>G polymorphisms and risk of early-onset preeclampsia (PE) and its complications. Methods. The study included 47 early-onset PE patients, which were grouped by disease severity and by size for gestational age and 47 control cases. The Val158Met polymorphism was genotyped by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) analysis and inflammatory cytokine polymorphisms by the Sanger sequencing method. Results. The COMT Met allele as well as IL-1 alpha T showed a protective role, decreasing the risk of early-onset PE after age and body mass index (BMI) adjustments. The detected interactions between the COMT Met and IL-10 A alleles, as well as between the COMT Met and TNF-alpha T alleles were insignificant after age and BMI adjustments. Conclusion. COMT and IL-1 alpha may be used as candidate genes for early-onset PE and its severe form and small for gestational age (SGA) complications. | en |
dc.publisher | Vojnomedicinska akademija - Institut za naučne informacije, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.source | Vojnosanitetski pregled | |
dc.title | Association between Val158Met COMT, TNF-alpha-857 C > T, TNFR1 36 A > G, IL-1 alpha 4845 G > T and IL-10-1082 A > G Polymorphisms and Risk of Early-Onset Preeclampsia and Its Complications | en |
dc.type | article | |
dc.rights.license | BY-SA | |
dcterms.abstract | Томасевић, Драгана; Топалов, Дрина; Мајкић-Сингх, Нада; Крњета, Тијана; Мирковић, Љиљана; Игњатовић, Светлана; Лукић, Јелена; | |
dc.citation.volume | 74 | |
dc.citation.issue | 12 | |
dc.citation.spage | 1155 | |
dc.citation.epage | 1161 | |
dc.citation.other | 74(12): 1155-1161 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000417270100009 | |
dc.identifier.doi | 10.2298/VSP160329313K | |
dc.identifier.scopus | 2-s2.0-85052673486 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1478/2846.pdf | |
dc.type.version | publishedVersion |