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dc.creatorParojčić, Jelena
dc.creatorĐurić, Zorica
dc.creatorJovanović, M
dc.creatorIbrić, Svetlana
dc.creatorNikolić, L
dc.date.accessioned2019-09-02T10:53:12Z
dc.date.available2019-09-02T10:53:12Z
dc.date.issued2001
dc.identifier.issn0031-711X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/284
dc.description.abstractDissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.en
dc.publisherECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
dc.rightsrestrictedAccess
dc.sourcePharmazeutische Industrie
dc.subjectAcetylsalicylic aciden
dc.subjectCAS 103-90-2en
dc.subjectCAS 50-78-2en
dc.subjectDissolution testing, experimental design, factorial designen
dc.subjectParacetamolen
dc.subjectTabletsen
dc.titleInfluence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial designen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНиколић, Л; Јовановић, М; Паројчић, Јелена; Ђурић, Зорица; Ибрић, Светлана;
dc.citation.volume63
dc.citation.issue7
dc.citation.spage774
dc.citation.epage779
dc.citation.other63(7): 774-779
dc.citation.rankM23
dc.identifier.wos000170308200004
dc.identifier.scopus2-s2.0-0034891108
dc.identifier.rcubconv_1326
dc.type.versionpublishedVersion


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