Prikaz osnovnih podataka o dokumentu
Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
dc.creator | Parojčić, Jelena | |
dc.creator | Đurić, Zorica | |
dc.creator | Jovanović, M | |
dc.creator | Ibrić, Svetlana | |
dc.creator | Nikolić, L | |
dc.date.accessioned | 2019-09-02T10:53:12Z | |
dc.date.available | 2019-09-02T10:53:12Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0031-711X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/284 | |
dc.description.abstract | Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape. | en |
dc.publisher | ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf | |
dc.rights | restrictedAccess | |
dc.source | Pharmazeutische Industrie | |
dc.subject | Acetylsalicylic acid | en |
dc.subject | CAS 103-90-2 | en |
dc.subject | CAS 50-78-2 | en |
dc.subject | Dissolution testing | en |
dc.subject | Paracetamol | en |
dc.subject | Tablets | en |
dc.subject | experimental design | en |
dc.subject | factorial design | en |
dc.title | Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Николић, Л; Јовановић, М; Паројчић, Јелена; Ђурић, Зорица; Ибрић, Светлана; | |
dc.citation.volume | 63 | |
dc.citation.issue | 7 | |
dc.citation.spage | 774 | |
dc.citation.epage | 779 | |
dc.citation.other | 63(7): 774-779 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000170308200004 | |
dc.identifier.scopus | 2-s2.0-0034891108 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_284 | |
dc.type.version | publishedVersion |
Dokumenti
Datoteke | Veličina | Format | Pregled |
---|---|---|---|
Uz ovaj zapis nema datoteka. |