Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed.
TY - JOUR
AU - Aleksić, Mirjana
AU - Agbaba, Danica
AU - Milojković-Opsenica, Dušanka
AU - Tešić, Živoslav
PY - 2001
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/285
AB - Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed.
PB - Vieweg, Wiesbaden
T2 - Chromatographia
T1 - Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents
VL - 53
IS - SPEC. ISS
DO - 10.1007/BF02490373
ER -
@article{
author = "Aleksić, Mirjana and Agbaba, Danica and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2001",
abstract = "Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed.",
publisher = "Vieweg, Wiesbaden",
journal = "Chromatographia",
title = "Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents",
volume = "53",
number = "SPEC. ISS",
doi = "10.1007/BF02490373"
}
Aleksić, M., Agbaba, D., Milojković-Opsenica, D.,& Tešić, Ž.. (2001). Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents. in Chromatographia
Vieweg, Wiesbaden., 53(SPEC. ISS).
https://doi.org/10.1007/BF02490373
Aleksić M, Agbaba D, Milojković-Opsenica D, Tešić Ž. Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents. in Chromatographia. 2001;53(SPEC. ISS).
doi:10.1007/BF02490373 .
Aleksić, Mirjana, Agbaba, Danica, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents" in Chromatographia, 53, no. SPEC. ISS (2001),
https://doi.org/10.1007/BF02490373 . .
