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dc.creatorMaksić, Jelena
dc.creatorStajić, Ana
dc.creatorKnežević, Miroslav
dc.creatorDacić-Krnjaja, Bojana
dc.creatorJančić-Stojanović, Biljana
dc.creatorMedenica, Mirjana
dc.date.accessioned2019-09-02T11:58:54Z
dc.date.available2019-09-02T11:58:54Z
dc.date.issued2017
dc.identifier.issn1757-6180
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2860
dc.description.abstractAim: The objective of the study was development of hydrophilic interaction liquid chromatography-ESI/MS/MS method for the determination of olopatadine in tear matrix. Materials & methods: Separation was performed on Acquity BEH amide column (2.1 x 100 mm, 1.7 mu m). The mobile phase was consisted of 0.1% formic acid in water and acetonitrile. Mianserin hydrochloride was implemented as an internal standard. The artificial tear fluid was used as matrix. The tear samples were collected using Schirmer test strips. For the optimization of ultra pressure liquid chromatography conditions, Box-Benhken design was utilized. Results: The optimal values of the ion source and collision cell parameters were found. Quantification was performed in multiple reaction monitoring mode. The optimized method was fully validated. Conclusion: The proposed method was utilized for monitoring of olopatadine in human tear.en
dc.publisherFuture Sci Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceBioanalysis
dc.subjectBox-Benhken designen
dc.subjecthuman tearsen
dc.subjecthydrophilic interaction liquid chromatographyen
dc.subjectolopatadineen
dc.subjectUPLC-MS/MSen
dc.titleDetermination of olopatadine in human tears by hydrophilic interaction liquid chromatography-MS/MS methoden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтајић, Aна; Кнежевић, Мирослав; Меденица, Мирјана; Дацић-Крњаја, Бојана; Максић, Јелена; Јанчић-Стојановић, Биљана;
dc.citation.volume9
dc.citation.issue24
dc.citation.spage1943
dc.citation.epage1954
dc.citation.other9(24): 1943-1954
dc.citation.rankM22
dc.identifier.wos000417836300003
dc.identifier.doi10.4155/bio-2017-0172
dc.identifier.pmid29205055
dc.identifier.scopus2-s2.0-85038389914
dc.identifier.rcubconv_4018
dc.type.versionpublishedVersion


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