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dc.creatorPopović, Dejana
dc.creatorDamjanović, Svetozar S.
dc.creatorĐorđević, Tea
dc.creatorMartić, Dejana
dc.creatorIgnjatović, Svetlana
dc.creatorMilinković, Neda
dc.creatorBanović, Marko
dc.creatorLasica, Ratko
dc.creatorPetrović, Milan
dc.creatorGuazzi, Marco
dc.creatorArena, Ross
dc.date.accessioned2019-09-02T11:58:55Z
dc.date.available2019-09-02T11:58:55Z
dc.date.issued2017
dc.identifier.issn1025-3890
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2861
dc.description.abstractObjectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects were subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS//
dc.rightsrestrictedAccess
dc.sourceSupportive Care in Cancer
dc.titleStress hormones at rest and following exercise testing predict coronary artery disease severity and outcomeen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилинковић, Неда; Гуаззи, Марцо; Aрена, Росс; Игњатовић, Светлана; Ласица, Ратко; Мартић, Дејана; Петровић, Милан; Бановић, Марко; Ђорђевић, Теа; Дамјановић, Светозар С.; Поповић, Дејана;
dc.citation.volume20
dc.citation.issue5
dc.citation.spage523
dc.citation.epage531
dc.citation.other20(5): 523-531
dc.citation.rankM22
dc.identifier.wos000418047600009
dc.identifier.doi10.1080/10253890.2017.1368488
dc.identifier.pmid28845719
dc.identifier.scopus2-s2.0-85028541384
dc.identifier.rcubconv_4020
dc.type.versionpublishedVersion


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