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Application of the fractional factorial design in multiple W/O/W emulsions

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Authors
Vasiljević, Dragana
Đuriš, Jelena
Jakimenko, Sergej
Ibrić, Svetlana
Article (Published version)
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Abstract
In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial... design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .

Source:
Journal of Dispersion Science and Technology, 2017, 38, 12, 1732-1737
Publisher:
  • Taylor & Francis Inc, Philadelphia
Projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)
Note:
  • Peer-reviewed manuscript: http://farfar.pharmacy.bg.ac.rs/handle/123456789/3445

DOI: 10.1080/01932691.2016.1278551

ISSN: 0193-2691

WoS: 000414942900010

Scopus: 2-s2.0-85017450551
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2862
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Pharmacy

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