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dc.creatorPopović, Dejana
dc.creatorMartić, Dejana
dc.creatorĐorđević, Tea
dc.creatorPešić, Vesna
dc.creatorGuazzi, Marco
dc.creatorMyers, Jonathan
dc.creatorMohebi, Reza
dc.creatorArena, Ross
dc.date.accessioned2019-09-02T11:59:19Z
dc.date.available2019-09-02T11:59:19Z
dc.date.issued2017
dc.identifier.issn0167-5273
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2877
dc.description.abstractBackground: Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. Methods: 40 Caucasian patients (21.2% females), mean age 63.5 +/- 7.6 with significant coronary artery lesions (>= 50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4 days apart; subjects were subsequently followed 32 +/- 10 months. Myocardial wall motion was recorded by echocardiography at rest and peak exercise. Ischemia was quantified by the wall motion score index (WMSI). Results: Mean ejection fraction was 56.7 +/- 9.6%. Patients with 1-2 stenotic coronary arteries (SCA) showed a poorer CPET response during the recovery phase than patients with 3-SCA. ROC analysis revealed the change of carbon-dioxide output (Delta VCO2) recovery/peak (area under ROC curve 0.77, p = 0.02, Sn = 87.5%, Sp = 70.4%) and oxygen uptake (Delta VO2) recovery/peak during TM CPET (area under ROC curve 0.76, p = 0.03, Sn 75.0%, Sp 77.8%) were significant in distinguishing between 1-2-SCA and 3-SCA. The same variables predicted.WMSI peak/rest on univariate analysis (p lt 0.05). Multivariate Cox analysis revealed a high predictive value of Delta VO2 recovery/peak obtained during TM CPET for composite endpoint of cumulative cardiac events (HR = 1.27, CI = 1.07-1.51, p = 0.008). Conclusions: The current study suggests CPET parameters in recovery hold predictive value for CAD severity and prognosis. TM testing seems to be a better approach in the assessment of CAD severity and prognosis.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Cardiology
dc.subjectCardiopulmonary exercise testen
dc.subjectCoronary artery diseaseen
dc.subjectCarbon-dioxideen
dc.subjectOxygen uptakeen
dc.subjectRecoveryen
dc.titleOxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcomeen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAрена, Росс; Пешић, Весна; Ђорђевић, Теа; Гуаззи, Марцо; Мyерс, Јонатхан; Поповић, Дејана; Мартић, Дејана; Мохеби, Реза;
dc.citation.volume248
dc.citation.spage39
dc.citation.epage45
dc.citation.other248: 39-45
dc.citation.rankM22
dc.identifier.wos000411439900007
dc.identifier.doi10.1016/j.ijcard.2017.06.107
dc.identifier.pmid28689985
dc.identifier.scopus2-s2.0-85021854467
dc.type.versionpublishedVersion


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