Show simple item record

dc.creatorOljačić, Slavica
dc.creatorArsić, Anđela
dc.creatorObradović, Darija
dc.creatorNikolić, Katarina
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:59:26Z
dc.date.available2019-09-02T11:59:26Z
dc.date.issued2017
dc.identifier.issn0933-4173
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2881
dc.description.abstractThe retention behavior and lipophilicity of aripiprazole and its nine impurities as well as ziprasidone and its five impurities have been examined by thin-layer chromatography using RP-18 stationary phase and different mixtures of methanol, water, and ammonia; and ethanol, water, and ammonia as the mobile phases. In both examined chromatographic systems, linear relationships were established between retention parameters and the volume fraction of the methanol and ethanol in mobile phase (r > 0.948 for methanol and r > 0.971 for ethanol). Correlation matrices obtained between experimentally obtained lipophilicity indices (R-M(0), m, and C-0) and calculated log P values showed that, for the examined antipsychotics and their impurities, R-M(0) and m values are more reliable lipophilicity parameters compared to C-0 values. In addition, the performed principal component analysis (PCA) has provided new information about the similarity and differences between the tested compounds as well as the experimental lipophilicity indices and calculated log P values. The experimentally obtained R-M(0) values and the computed molecular parameters of the examined compounds were further used for the quantitative structure-retention relationship (QSRR) study in order to determine the most important properties governing retention. The QSRR modeling was performed by use of the partial least squares regression, and predictive performances of the developed QSRR models were tested by use of the cross-validation and external test set prediction. The obtained results revealed that, apart from lipophilicity, topological descriptors and molecular weights of the tested compounds have the strongest influence on the retention behavior of the examined antipsychotics and their impurities in reversed-phase thin-layer chromatography. The predictive performance of the developed QSRR model suggests its applicability for a reliable prediction of the retention behavior of the congeners.en
dc.publisherAkademiai Kiado Rt, Budapest
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Planar Chromatography - Modern TLC
dc.subjectAntipsychoticsen
dc.subjectImpuritiesen
dc.subjectLipophilicityen
dc.subjectReversed-phase thin-layer chromatographyen
dc.subjectQuantitative structure-retention relationshipen
dc.titleAnalysis of the Retention Behavior of Selected Antipsychotics and Their Impurities by Thin-Layer Chromatographyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОбрадовић, Дарија; Ољачић, Славица; Aрсић, Aнђела; Aгбаба, Даница; Николић, Катарина;
dc.citation.volume30
dc.citation.issue5
dc.citation.spage340
dc.citation.epage349
dc.citation.other30(5): 340-349
dc.citation.rankM23
dc.identifier.wos000411400700004
dc.identifier.doi10.1556/1006.2017.30.5.2
dc.identifier.scopus2-s2.0-85029794201
dc.identifier.rcubconv_3948
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record