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Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers

Authorized Users Only
2017
Authors
Milić, Jela
Čalija, Bojan
Đorđević, Sanela
Book part (Published version)
Metadata
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Abstract
Continuous efforts to improve performance of drugs via incorporation in particulate and soft colloidal carriers have introduced new functional categories of excipients. These excipients are used to protect drugs, modify their release, and increase their bioavailability and/or selectivity for target tissues with the aim to improve patient compliance, and therapeutic outcomes. Structural and physicochemical variability of these materials may affect their functionality in the final formulation. Therefore, it is of great importance to identify, evaluate, and control physical or chemical characteristics of excipients that are important for their intended use. These characteristics are known as functionality-related characteristics of excipients.This chapter gives an overview of characteristics and variability of the three distinct groups of excipients commonly used for preparation of particulate and soft colloidal carriers: biodegradable polymeric materials, silica-based materials, and natu...ral surfactants. Special attention is paid to functionality, functionality-related characteristics, and functionalization of these materials in relation to their use for preparation of micro/nanosized drug carriers.

Keywords:
Biodegradable polymers / Excipients functionality / Functionality-related characteristics / Microemulsions / Microparticles / Nanoemulsions / Nanoparticles / Natural surfactants / Silica-based materials
Source:
Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a, 2017, 95-132
Publisher:
  • Elsevier Inc.
Funding / projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)

DOI: 10.1016/B978-0-12-804017-1.00004-2

Scopus: 2-s2.0-85020534547
[ Google Scholar ]
7
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2893
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - CHAP
AU  - Milić, Jela
AU  - Čalija, Bojan
AU  - Đorđević, Sanela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2893
AB  - Continuous efforts to improve performance of drugs via incorporation in particulate and soft colloidal carriers have introduced new functional categories of excipients. These excipients are used to protect drugs, modify their release, and increase their bioavailability and/or selectivity for target tissues with the aim to improve patient compliance, and therapeutic outcomes. Structural and physicochemical variability of these materials may affect their functionality in the final formulation. Therefore, it is of great importance to identify, evaluate, and control physical or chemical characteristics of excipients that are important for their intended use. These characteristics are known as functionality-related characteristics of excipients.This chapter gives an overview of characteristics and variability of the three distinct groups of excipients commonly used for preparation of particulate and soft colloidal carriers: biodegradable polymeric materials, silica-based materials, and natural surfactants. Special attention is paid to functionality, functionality-related characteristics, and functionalization of these materials in relation to their use for preparation of micro/nanosized drug carriers.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers
SP  - 95
EP  - 132
DO  - 10.1016/B978-0-12-804017-1.00004-2
ER  - 
@inbook{
author = "Milić, Jela and Čalija, Bojan and Đorđević, Sanela",
year = "2017",
abstract = "Continuous efforts to improve performance of drugs via incorporation in particulate and soft colloidal carriers have introduced new functional categories of excipients. These excipients are used to protect drugs, modify their release, and increase their bioavailability and/or selectivity for target tissues with the aim to improve patient compliance, and therapeutic outcomes. Structural and physicochemical variability of these materials may affect their functionality in the final formulation. Therefore, it is of great importance to identify, evaluate, and control physical or chemical characteristics of excipients that are important for their intended use. These characteristics are known as functionality-related characteristics of excipients.This chapter gives an overview of characteristics and variability of the three distinct groups of excipients commonly used for preparation of particulate and soft colloidal carriers: biodegradable polymeric materials, silica-based materials, and natural surfactants. Special attention is paid to functionality, functionality-related characteristics, and functionalization of these materials in relation to their use for preparation of micro/nanosized drug carriers.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers",
pages = "95-132",
doi = "10.1016/B978-0-12-804017-1.00004-2"
}
Milić, J., Čalija, B.,& Đorđević, S.. (2017). Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 95-132.
https://doi.org/10.1016/B978-0-12-804017-1.00004-2
Milić J, Čalija B, Đorđević S. Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:95-132.
doi:10.1016/B978-0-12-804017-1.00004-2 .
Milić, Jela, Čalija, Bojan, Đorđević, Sanela, "Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):95-132,
https://doi.org/10.1016/B978-0-12-804017-1.00004-2 . .

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