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dc.creatorArsenović-Ranin, Nevena
dc.creatorKosec, Duško
dc.creatorPilipović, Ivan
dc.creatorNacka-Aleksić, Mirjana
dc.creatorBufan, Biljana
dc.creatorStojić-Vukanić, Zorica
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:59:53Z
dc.date.available2019-09-02T11:59:53Z
dc.date.issued2017
dc.identifier.issn0300-8177
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2898
dc.description.abstractThe study examined the influence of age, sex and peripubertal gonadectomy on a set of T-cell phenotypic parameters. Rats of both sexes were gonadectomised at the age of 1 month and peripheral blood and spleen T lymphocytes from non-gonadectomised and gonadectomised 3- and 11-month-old rats were examined for the expression of differentiation/activation (CD90/CD45RC) and immunoregulatory markers. Peripheral blood T lymphocytes from non-gonadectomised rats showed age-dependent sexual dimorphisms in (1) total count (lower in female than male 11-month-old rats); (2) CD4+:CD8 + cell ratio (higher in female than male rats of both ages); (3) the proportion of recent thymic emigrants in CD8 + T cells (lower in female than male 3-month-old rats) and (4) the proportions of mature na lt ve and memory/activated cells (irrespective of age, the proportion of na lt ve cells was higher, whereas that of memory/activated cells was lower in females). Gonadectomy influenced magnitudes or direction of these sex differences. Additionally, sex differences in peripheral blood T-lymphocyte parameters did not fully correspond to those observed in T-splenocyte parameters, suggesting the compartment-specific regulation of the major T-cell subpopulations' and their subsets' composition. Furthermore, there was no sexual dimorphism in the proportion of either CD25 + Foxp3 + cells among CD4 + or CD161+ (NKT) cells within CD8 + T lymphocytes. However, there was gonadal hormone-independent age-associated sexual dimorphism in the proportion of CD161 + cells (NKT cells) in CD8 + T splenocytes. Overall, the study revealed age-dependent variations in sexual dimorphisms in T-cell parameters relevant for immune response efficacy and showed that they are T-cell compartment-specific and partly gonadal hormone-related.en
dc.publisherSpringer, Dordrecht
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceMolecular and Cellular Biochemistry
dc.subjectCD4:CD8+T-cell ratioen
dc.subjectRecent thymic emigrantsen
dc.subjectRegulatory T cellsen
dc.subjectSex differencesen
dc.subjectGonadectomyen
dc.titleSex and age as determinants of rat T-cell phenotypic characteristics: influence of peripubertal gonadectomyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКосец, Душко; Стојић-Вуканић, Зорица; Пилиповић, Иван; Нацка-Aлексић, Мирјана; Aрсеновић-Ранин, Невена; Лепосавић, Гордана; Буфан, Биљана;
dc.citation.volume431
dc.citation.issue1-2
dc.citation.spage169
dc.citation.epage185
dc.citation.other431(1-2): 169-185
dc.citation.rankM23
dc.identifier.wos000403416000019
dc.identifier.doi10.1007/s11010-017-2989-x
dc.identifier.pmid28281185
dc.identifier.scopus2-s2.0-85014637872
dc.identifier.rcubconv_3796
dc.type.versionpublishedVersion


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