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The Effect of Nonionic Surfactant Brij 35 on Solubility and Acid-Base Equilibria of Verapamil

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2017
Authors
Popović-Nikolić, Marija
Popović, Gordana
Agbaba, Danica
Article (Published version)
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Abstract
Protolytic equilibria and solubility of verapamil were investigated in the presence and in the absence of nonionic surfactant Brij 35 at a constant ionic strength (0.1 mol/L NaCl) and temperature 25 degrees C. In surfactant free media the intrinsic solubility, S-o = 4.51 X 10(-5) mol/L (only the neutral form is present in the solution) and pH dependent solubility, S (neutral and ionized form in solution) of verapamil were determined. On the basis of the solubility data, the apparent pK(a) value 9.15 of verapamil was indirectly obtained. In micellar media (10(-3) mol/L Brij 35) the solubility of verapamil free base (S-0,S-s = 2.76 X 10(-3) mol/L) and the apparent pK(a,s) = 6.35, were determined. The shift in the protolytic equilibria (Delta pK(a) = -2.80) and the increased solubility of verapamil free base (approximately 60 times) caused by Brij 35 point out to specific interactions between verapamil and the inner part of Brij 35 micelles. The most significant changes in distribution of... verapamil equilibrium forms were observed at biopharmaceutically important pH 7.4 which potentially indicates interactions with biomolecules in blood plasma.

Source:
Journal of Chemical and Engineering Data, 2017, 62, 6, 1776-1781
Publisher:
  • Amer Chemical Soc, Washington
Projects:
  • Synthesis, Quantitative Structure and Activity Relationship, Physico-Chemical Characterisation and Analysis of Pharmacologically Active Substances (RS-172033)

DOI: 10.1021/acs.jced.6b00864

ISSN: 0021-9568

WoS: 000403192100005

Scopus: 2-s2.0-85021058774
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2899
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Pharmacy

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