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dc.creatorŽivković, Lada
dc.creatorBorozan, Sunčica
dc.creatorPirković, Andrea
dc.creatorTopalović, Dijana
dc.creatorCiptasari, Ummi
dc.creatorBajić, Vladan
dc.creatorPotparević, Biljana
dc.date.accessioned2019-09-02T12:00:06Z
dc.date.available2019-09-02T12:00:06Z
dc.date.issued2017
dc.identifier.issn1942-0900
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2906
dc.description.abstractThe ability of Agaricus blazei mushroom in its dried and powdered mycelial form was evaluated for its antigenotoxic properties for the first time. Antigenotoxic effects in human peripheral blood cells against H2O2-induced DNA damage were examined in pretreatment and posttreatment protocol by comet assay. The results showed better antigenotoxic properties of Agaricus blazei on the interventional level, respectively, after treatment. Agaricus blazei in concentration of 250 mu g/mL after treatment was most efficient in regard to its action against DNA damage. The evaluation of repair kinetics showed decrease in H2O2 induced DNA damage 15min after the application of A. blazei, reaching the maximum potency after 30 min. Analysis of antioxidant properties of Agaricus blazei revealed strong center dot OH scavenging properties and moderate reducing power, while its DPPH scavenging ability was weak. In regard to our findings, we can conclude that our preliminary results demonstrated antigenotoxic properties of Agaricus blazei and its strong center dot OH scavenging ability. Mechanisms underlying its properties should be further evaluated in in vivo studies.en
dc.publisherHindawi Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsopenAccess
dc.sourceOxidative Medicine and Cellular Longevity
dc.titleAntigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cellsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractТопаловић, Дијана; Борозан, Сунчица; Пирковић, Aндреа; Живковић, Лада; Потпаревић, Биљана; Бајић, Владан; Циптасари, Умми;
dc.citation.rankM21
dc.identifier.wos000396254900001
dc.identifier.doi10.1155/2017/8759764
dc.identifier.pmid28316757
dc.identifier.scopus2-s2.0-85018611452
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1524/2904.pdf
dc.identifier.rcubconv_3782
dc.type.versionpublishedVersion


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