Приказ основних података о документу

dc.creatorJorgačević, B
dc.creatorVučević, D
dc.creatorĐuričić, Ivana
dc.creatorŠobajić, Slađana
dc.creatorMladenović, Dušan
dc.creatorVesković, M
dc.creatorVukićević, R.J
dc.creatorRadosavljević, Tatjana S.
dc.date.accessioned2019-09-02T12:00:19Z
dc.date.available2019-09-02T12:00:19Z
dc.date.issued2017
dc.identifier.issn0009-3084
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2915
dc.description.abstractWe used rimonabant to investigate the role of CB1 receptor on hepatic FFAs profile during NAFLD. Male mice C57BL/6 were divided into: control group fed with control diet 20 weeks (C; n = 6); group fed with HFD 20 weeks (HF; n = 6); group fed with control diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Rimonabant (10 mg/kg) was administered daily to HFR and R group by oral gavage. Rimonabant decreased liver palmitic acid proportion in HFR group compared to HF group (p  lt  0.05). Liver stearic and oleic acid proportions were decreased in R group compared to control (p  lt  0.01 respectively). Rimonabant increased liver linoleic and arachidonic acid proportions in HFR group compared to HF group (p  lt  0.01 respectively). CB1 blockade may be useful in the treatment of HFD-induced NAFLD due to modulation of plasma lipid and hepatic FFA profile.en
dc.publisherElsevier Ireland Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175015/RS//
dc.rightsrestrictedAccess
dc.sourceChemistry and Physics of Lipids
dc.subjectCB1 receptor blockadeen
dc.subjectEndocannabinoid systemen
dc.subjectFree fatty acid profileen
dc.subjectMiceen
dc.subjectNAFLDen
dc.subjectRimonabanten
dc.titleThe effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМладеновић, Душан; Вукићевић, Р.Ј; Весковић, М; Ђуричић, Ивана; Вучевић, Д; Јоргачевић, Б; Радосављевић, Татјана С.; Шобајић, Слађана;
dc.citation.volume204
dc.citation.spage85
dc.citation.epage93
dc.citation.other204: 85-93
dc.citation.rankM22
dc.identifier.wos000400530000010
dc.identifier.doi10.1016/j.chemphyslip.2017.03.009
dc.identifier.scopus2-s2.0-85017112176
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу