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The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease
dc.creator | Jorgačević, B | |
dc.creator | Vučević, D | |
dc.creator | Đuričić, Ivana | |
dc.creator | Šobajić, Slađana | |
dc.creator | Mladenović, Dušan | |
dc.creator | Vesković, M | |
dc.creator | Vukićević, R.J | |
dc.creator | Radosavljević, Tatjana S. | |
dc.date.accessioned | 2019-09-02T12:00:19Z | |
dc.date.available | 2019-09-02T12:00:19Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0009-3084 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2915 | |
dc.description.abstract | We used rimonabant to investigate the role of CB1 receptor on hepatic FFAs profile during NAFLD. Male mice C57BL/6 were divided into: control group fed with control diet 20 weeks (C; n = 6); group fed with HFD 20 weeks (HF; n = 6); group fed with control diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Rimonabant (10 mg/kg) was administered daily to HFR and R group by oral gavage. Rimonabant decreased liver palmitic acid proportion in HFR group compared to HF group (p lt 0.05). Liver stearic and oleic acid proportions were decreased in R group compared to control (p lt 0.01 respectively). Rimonabant increased liver linoleic and arachidonic acid proportions in HFR group compared to HF group (p lt 0.01 respectively). CB1 blockade may be useful in the treatment of HFD-induced NAFLD due to modulation of plasma lipid and hepatic FFA profile. | en |
dc.publisher | Elsevier Ireland Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175015/RS// | |
dc.rights | restrictedAccess | |
dc.source | Chemistry and Physics of Lipids | |
dc.subject | CB1 receptor blockade | en |
dc.subject | Endocannabinoid system | en |
dc.subject | Free fatty acid profile | en |
dc.subject | Mice | en |
dc.subject | NAFLD | en |
dc.subject | Rimonabant | en |
dc.title | The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Младеновић, Душан; Вукићевић, Р.Ј; Весковић, М; Ђуричић, Ивана; Вучевић, Д; Јоргачевић, Б; Радосављевић, Татјана С.; Шобајић, Слађана; | |
dc.citation.volume | 204 | |
dc.citation.spage | 85 | |
dc.citation.epage | 93 | |
dc.citation.other | 204: 85-93 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000400530000010 | |
dc.identifier.doi | 10.1016/j.chemphyslip.2017.03.009 | |
dc.identifier.scopus | 2-s2.0-85017112176 | |
dc.type.version | publishedVersion |