Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
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2017
Authors
Ismaili, LRefouvelet, B
Benchekroun, M
Brogi, S
Brindisi, M
Gemma, S
Campiani, G
Filipić, Slavica

Agbaba, Danica

Esteban, Gerard
Unzeta, Mercedes

Nikolić, Katarina

Butini, Stefania

Marco-Contelles, Jose
Article (Published version)

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Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years fo...cusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures.
Keywords:
Acetylcholinesterase / Alzheimer's disease / Beta secretase / Butyrylcholinesterase / Cholinesterases / Histamine receptor / Monoamine oxidases / Multi-target-directed ligand / Nitric oxide / Reactive oxySource:
Progress in Neurobiology, 2017, 151, 4-34Publisher:
- Elsevier Ltd
Funding / projects:
DOI: 10.1016/j.pneurobio.2015.12.003
ISSN: 0301-0082
WoS: 000399420800002
Scopus: 2-s2.0-84956685110
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PharmacyTY - JOUR AU - Ismaili, L AU - Refouvelet, B AU - Benchekroun, M AU - Brogi, S AU - Brindisi, M AU - Gemma, S AU - Campiani, G AU - Filipić, Slavica AU - Agbaba, Danica AU - Esteban, Gerard AU - Unzeta, Mercedes AU - Nikolić, Katarina AU - Butini, Stefania AU - Marco-Contelles, Jose PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2916 AB - Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures. PB - Elsevier Ltd T2 - Progress in Neurobiology T1 - Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease VL - 151 SP - 4 EP - 34 DO - 10.1016/j.pneurobio.2015.12.003 ER -
@article{ author = "Ismaili, L and Refouvelet, B and Benchekroun, M and Brogi, S and Brindisi, M and Gemma, S and Campiani, G and Filipić, Slavica and Agbaba, Danica and Esteban, Gerard and Unzeta, Mercedes and Nikolić, Katarina and Butini, Stefania and Marco-Contelles, Jose", year = "2017", abstract = "Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures.", publisher = "Elsevier Ltd", journal = "Progress in Neurobiology", title = "Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease", volume = "151", pages = "4-34", doi = "10.1016/j.pneurobio.2015.12.003" }
Ismaili, L., Refouvelet, B., Benchekroun, M., Brogi, S., Brindisi, M., Gemma, S., Campiani, G., Filipić, S., Agbaba, D., Esteban, G., Unzeta, M., Nikolić, K., Butini, S.,& Marco-Contelles, J.. (2017). Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. in Progress in Neurobiology Elsevier Ltd., 151, 4-34. https://doi.org/10.1016/j.pneurobio.2015.12.003
Ismaili L, Refouvelet B, Benchekroun M, Brogi S, Brindisi M, Gemma S, Campiani G, Filipić S, Agbaba D, Esteban G, Unzeta M, Nikolić K, Butini S, Marco-Contelles J. Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. in Progress in Neurobiology. 2017;151:4-34. doi:10.1016/j.pneurobio.2015.12.003 .
Ismaili, L, Refouvelet, B, Benchekroun, M, Brogi, S, Brindisi, M, Gemma, S, Campiani, G, Filipić, Slavica, Agbaba, Danica, Esteban, Gerard, Unzeta, Mercedes, Nikolić, Katarina, Butini, Stefania, Marco-Contelles, Jose, "Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease" in Progress in Neurobiology, 151 (2017):4-34, https://doi.org/10.1016/j.pneurobio.2015.12.003 . .