Show simple item record

dc.creatorIsmaili, L
dc.creatorRefouvelet, B
dc.creatorBenchekroun, M
dc.creatorBrogi, S
dc.creatorBrindisi, M
dc.creatorGemma, S
dc.creatorCampiani, G
dc.creatorFilipić, Slavica
dc.creatorAgbaba, Danica
dc.creatorEsteban, Gerard
dc.creatorUnzeta, Mercedes
dc.creatorNikolić, Katarina
dc.creatorButini, Stefania
dc.creatorMarco-Contelles, Jose
dc.date.accessioned2019-09-02T12:00:20Z
dc.date.available2019-09-02T12:00:20Z
dc.date.issued2017
dc.identifier.issn0301-0082
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2916
dc.description.abstractAlzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures.en
dc.publisherElsevier Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceProgress in Neurobiology
dc.subjectAcetylcholinesteraseen
dc.subjectAlzheimer's diseaseen
dc.subjectBeta secretaseen
dc.subjectButyrylcholinesteraseen
dc.subjectCholinesterasesen
dc.subjectHistamine receptoren
dc.subjectMonoamine oxidasesen
dc.subjectMulti-target-directed liganden
dc.subjectNitric oxideen
dc.subjectReactive oxyen
dc.titleMultitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРефоувелет, Б; Николић, Катарина; Унзета, Мерцедес; Исмаили, Л; Филипић, Славица; Броги, С; Бриндиси, М; Естебан, Герард; Гемма, С; Aгбаба, Даница; Бенцхекроун, М; Марцо-Цонтеллес, Јосе; Цампиани, Г; Бутини, Стефаниа;
dc.citation.volume151
dc.citation.spage4
dc.citation.epage34
dc.citation.other151: 4-34
dc.citation.rankaM21
dc.identifier.wos000399420800002
dc.identifier.doi10.1016/j.pneurobio.2015.12.003
dc.identifier.scopus2-s2.0-84956685110
dc.identifier.rcubconv_4565
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record