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dc.creatorPetrović, Milan
dc.creatorPetrović, Marija
dc.creatorMilasinović, Goran
dc.creatorVujisić-Tesić, Bosiljka
dc.creatorTrifunović, Danijela
dc.creatorPetrović, Olga
dc.creatorNedeljković, Ivana
dc.creatorPetrović, Ivana
dc.creatorBanović, Marko
dc.creatorBoricić-Kostić, Marija
dc.creatorPetrović, Jelena
dc.creatorArena, Ross
dc.creatorPopović, Dejana
dc.date.accessioned2019-09-02T12:00:25Z
dc.date.available2019-09-02T12:00:25Z
dc.date.issued2017
dc.identifier.issn0742-2822
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2918
dc.description.abstractAims: Selection of patients who are viable candidates for cardiac resynchronization therapy (CRT), prediction of the response to CRT as well as an optimal definition of a favorable response, all require further exploration. The purpose of this study was to evaluate the interplay between the prediction of the response to CRT and the definition of a favorable outcome. Methods: Seventy patients who received CRT were included. All patients met current guideline criteria for CRT. Forty-three echocardiographic parameters were evaluated before CRT and at 1, 3, 6, and 12 months. M-mode, 2D echocardiography, and Doppler imaging were used to quantify left ventricular (LV) systolic and diastolic function, mitral regurgitation, right ventricular systolic function, pulmonary artery pressure, and myocardial mechanical dyssynchrony. The following definitions of a favorable CRT response were used: left ventricular ejection fraction (LVEF) improvement more >5% acutely following CRT, LVEF improvement >20% at 12-month follow-up, and a LV end-systolic volume (LVESV) decrease >15% at 12-month follow-up. Results: For the LVEF improvement >5%, the best predictor was isovolumetric relaxation time (IVRT; P=.035). For improvement of LVEF >20%, the best predictors were left ventricular stroke index (LVSI; P=.044) and left ventricular fractional shortening (LVFS; P=.031). For the drop in left ventricular systolic volume (LVESV >15%), the best predictor was septal-to-lateral wall delay (Delta T) (P=.043, RR=1.023, 95% CI for RR=1.001-1.045). Conclusion: The definition of a favorable CRT response influenced the optimal predictor variable(s). Standardization of defining a favorable response to CRT is needed to guide clinical decision making processes.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175086/RS//
dc.rightsrestrictedAccess
dc.sourceEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
dc.titleGauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcomeen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиласиновић, Горан; Aрена, Росс; Петровић, Ивана; Поповић, Дејана; Трифуновић, Данијела; Петровић, Милан; Петровић, Јелена; Петровић, Олга; Недељковић, Ивана; Вујисић-Тесић, Босиљка; Бановић, Марко; Борицић-Костић, Марија; Петровић, Марија;
dc.citation.volume34
dc.citation.issue3
dc.citation.spage371
dc.citation.epage375
dc.citation.other34(3): 371-375
dc.citation.rankM23
dc.identifier.wos000398109300007
dc.identifier.doi10.1111/echo.13453
dc.identifier.pmid28075037
dc.identifier.scopus2-s2.0-85010338822
dc.type.versionpublishedVersion


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