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dc.creatorSavić, Jelena
dc.creatorDobričić, Vladimir
dc.creatorNikolić, Katarina
dc.creatorVladimirov, Sote
dc.creatorDilber, Sanda
dc.creatorBrborić, Jasmina
dc.date.accessioned2019-09-02T12:00:33Z
dc.date.available2019-09-02T12:00:33Z
dc.date.issued2017
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2923
dc.description.abstractPrediction of gastrointestinal absorption of thirteen newly synthesized beta-hydroxy-beta-arylalkanoic acids (HAA) and ibuprofen was performed using PAMPA test The highest values of PAMPA parameters (%Tand P-app) were calculated for 1C, 1B and 2C and these parameters were significantly lower in comparison to ibuprofen. QSPR analysis was performed in order to identify molecular descriptors with the highest influence on %Tand-logP(app) and to create models which could be used for the design of novel HAA with improved gastrointestinal absorption. Obtained results indicate that introduction of branched side chain, as well as introduction of substituents on one phenyl ring (which disturb symmetry of the molecule) could have positive impact on gastrointestinal absorption. On the basis of these results, six novel HAA were designed and PAMPA parameters %Tand-logP(app) were predicted by use of selected QSPR models. Designed derivatives should have better gastrointestinal absorption than HAA tested in this study.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.titleIn vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA techniqueen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавић, Јелена; Дилбер, Санда; Владимиров, Соте; Добричић, Владимир; Брборић, Јасмина; Николић, Катарина;
dc.citation.volume100
dc.citation.spage36
dc.citation.epage41
dc.citation.other100: 36-41
dc.citation.rankM21
dc.identifier.wos000397373900005
dc.identifier.doi10.1016/j.ejps.2017.01.005
dc.identifier.pmid28077276
dc.identifier.scopus2-s2.0-85009360414
dc.identifier.rcubconv_3806
dc.type.versionpublishedVersion


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