Antifungal, Antioxidative, and Genoprotective Properties of Extracts from the Blushing Bracket Mushroom, Daedaleopsis confragosa (Agaricomycetes)
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Authors
Knežević, Aleksandar
Stajić, Mirjana

Živković, Lada

Milovanović, Ivan
Potparević, Biljana

Vukojević, Jelena

Article (Published version)

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This study aimed to evaluate the antifungal, antioxidative, and genoprotective potentials of various extracts of Daedaleopsis confragosa fruiting bodies and mycelia. The extracts exhibited weak fungistatic and an absence of any fungicidal activities against 7 important animal and human pathogens. Although mycelial extracts, especially the hot water extract, were more effective antifungal agents than basidiocarp extracts, they were significantly weaker than the commercial antimycotic ketoconazole. The tested extracts reduced DPPH radicals to various extents, depending on the material used for extraction and the solvent. The mycelial hot water extract was the best DPPH radical scavenger (half-maximal effective concentration, 3.42 mg mL-1), whereas the 96% ethanol extract of basidiocarps was the weakest one (half-maximal effective concentration, 5.36 mg mL-1). Phenols were the main carriers of activity, and their proportions in the tested extract mainly depended on the type and concentrat...ion of the solvent; the effect of the material used for extraction was negligible. The largest amount of phenols was detected in the 70% ethanol extract of basidiocarps (126.40 mu g gallic acid equivalents mg-1) and the lowest in the basidiocarp methanol extract (19.93 mu g gallic acid equivalents mg-1). Aqueous extracts of basidiocarp and mycelial extracts were not genotoxic agents but exhibited significant protective activity against hydrogen peroxide-induced DNA damage during use in leukocytes' pre-and post-treatments.
Source:
International Journal of Medicinal Mushrooms, 2017, 19, 6, 509-520Publisher:
- Begell House Inc, Danbury
Projects:
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-173032)
DOI: 10.1615/IntJMedMushrooms.v19.i6.30
ISSN: 1521-9437
PubMed: 29199561