A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2001, 24, 5-6, 993-998
TY - JOUR
AU - Marinković, Valentina
AU - Agbaba, Danica
AU - Vladimirov, S
AU - Stanković, S
PY - 2001
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/294
AB - A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Journal of Pharmaceutical and Biomedical Analysis
T1 - Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis
VL - 24
IS - 5-6
SP - 993
EP - 998
DO - 10.1016/S0731-7085(00)00531-8
ER -
@article{
author = "Marinković, Valentina and Agbaba, Danica and Vladimirov, S and Stanković, S",
year = "2001",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/294",
abstract = "A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis",
volume = "24",
number = "5-6",
pages = "993-998",
doi = "10.1016/S0731-7085(00)00531-8"
}
Marinković, V., Agbaba, D., Vladimirov, S.,& Stanković, S. (2001). Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis.
Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 993-998.
https://doi.org/10.1016/S0731-7085(00)00531-8
Marinković V, Agbaba D, Vladimirov S, Stanković S. Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis. Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):993-998
Marinković Valentina, Agbaba Danica, Vladimirov S, Stanković S, "Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis" Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):993-998,
https://doi.org/10.1016/S0731-7085(00)00531-8 .
