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Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis

Authorized Users Only
2001
Authors
Marinković, Valentina
Agbaba, Danica
Vladimirov, S
Stanković, S
Article (Published version)
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Abstract
A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2001, 24, 5-6, 993-998
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/S0731-7085(00)00531-8

ISSN: 0731-7085

PubMed: 11248493

WoS: 000167764200028

Scopus: 2-s2.0-0035089540
[ Google Scholar ]
16
11
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/294
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Marinković, Valentina
AU  - Agbaba, Danica
AU  - Vladimirov, S
AU  - Stanković, S
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/294
AB  - A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis
VL  - 24
IS  - 5-6
SP  - 993
EP  - 998
DO  - 10.1016/S0731-7085(00)00531-8
ER  - 
@article{
author = "Marinković, Valentina and Agbaba, Danica and Vladimirov, S and Stanković, S",
year = "2001",
abstract = "A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis",
volume = "24",
number = "5-6",
pages = "993-998",
doi = "10.1016/S0731-7085(00)00531-8"
}
Marinković, V., Agbaba, D., Vladimirov, S.,& Stanković, S.. (2001). Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 993-998.
https://doi.org/10.1016/S0731-7085(00)00531-8
Marinković V, Agbaba D, Vladimirov S, Stanković S. Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis. in Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):993-998.
doi:10.1016/S0731-7085(00)00531-8 .
Marinković, Valentina, Agbaba, Danica, Vladimirov, S, Stanković, S, "Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis" in Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):993-998,
https://doi.org/10.1016/S0731-7085(00)00531-8 . .

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