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dc.creatorAngelova, Violina T.
dc.creatorValcheva, Violeta
dc.creatorVassilev, Nikolay G.
dc.creatorBuyukliev, Rosen
dc.creatorMomekov, Georgi
dc.creatorDimitrov, Ivan
dc.creatorSaso, Luciano
dc.creatorĐukić, Mirjana
dc.creatorShivachev, Boris
dc.date.accessioned2019-09-02T12:00:57Z
dc.date.available2019-09-02T12:00:57Z
dc.date.issued2017
dc.identifier.issn0960-894X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2940
dc.description.abstractThis study reports the synthesis of new 2H-chromene or coumarin based acylhydrazones, which were evaluated for their in vitro antimycobacterial activity against reference strain Mycobacterium tuberculosis H37Rv and compared to the first-line antituberculosis drugs, isoniazid (INH) and ethambutol (EMB). The most active compounds 7m (MIC 0.13 mu M), 7o (MIC 0.15 mu M) and 7k (MIC 0.17 mu M) demonstrated antimycobacterial activity at submicromolar concentration level and remarkably minimal associated cytotoxicity in the human embryonic kidney cell line HEK-293T. Structure-activity relationship for this class of compounds has been established.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationNational Research Fund of Bulgaria - UNA-17/2005
dc.rightsrestrictedAccess
dc.sourceBioorganic & Medicinal Chemistry Letters
dc.titleAntimycobacterial activity of novel hydrazide-hydrazone derivatives with 2H-chromene and coumarin scaffolden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAнгелова, Виолина Т.; Сасо, Луциано; Схивацхев, Борис; Вассилев, Николаy Г.; Ђукић, Мирјана; Буyуклиев, Росен; Валцхева, Виолета; Момеков, Георги; Димитров, Иван;
dc.citation.volume27
dc.citation.issue2
dc.citation.spage223
dc.citation.epage227
dc.citation.other27(2): 223-227
dc.citation.rankM22
dc.identifier.wos000392558500021
dc.identifier.doi10.1016/j.bmcl.2016.11.071
dc.identifier.pmid27914798
dc.identifier.scopus2-s2.0-85006911003
dc.identifier.rcubconv_3747
dc.type.versionpublishedVersion


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