Show simple item record

dc.creatorĆurčić, Marijana
dc.creatorBuha, Aleksandra
dc.creatorStanković, Sanja
dc.creatorMilovanović, Vesna
dc.creatorBulat, Zorica
dc.creatorĐukić-Ćosić, Danijela
dc.creatorAntonijević, Evica
dc.creatorVucnić, Slavica
dc.creatorMatović, Vesna
dc.creatorAntonijević, Biljana
dc.date.accessioned2019-09-02T12:01:12Z
dc.date.available2019-09-02T12:01:12Z
dc.date.issued2017
dc.identifier.issn0300-483X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2948
dc.description.abstractThe objective of this study was to assess toxicity of Cd and BDE-209 mixture on haematological parameters in subacutely exposed rats and to determine the presence and type of interactions between these two chemicals using multiple factorial regression analysis. Furthermore, for the assessment of interaction type, an isobologram based methodology was applied and compared with multiple factorial regression analysis. Chemicals were given by oral gavage to the male Wistar rats weighing 200-240g for 28 days. Animals were divided in 16 groups (8/group): control vehiculum group, three groups of rats were treated with 2.5, 7.5 or 15 mg Cd/kg/day. These doses were chosen on the bases of literature data and reflect relatively high Cd environmental exposure, three groups of rats were treated with 1000, 2000 or 4000 mg BDE-209/kg/bw/day, doses proved to induce toxic effects in rats. Furthermore, nine groups of animals were treated with different mixtures of Cd and BDE-209 containing doses of Cd and BDE-209 stated above. Blood samples were taken at the end of experiment and red blood cells, white blood cells and platelets counts were determined. For interaction assessment multiple factorial regression analysis and fitted isobologram approach were used. In this study, we focused on multiple factorial regression analysis as a method for interaction assessment. We also investigated the interactions between Cd and BDE-209 by the derived model for the description of the obtained fitted isobologram curves. Current study indicated that co-exposure to Cd and BDE-209 can result in significant decrease in RBC count, increase in WBC count and decrease in PLT count, when compared with controls. Multiple factorial regression analysis used for the assessment of interactions type between Cd and BDE-209 indicated synergism for the effect on RBC count and no interactions i.e. additivity for the effects on WBC and PLT counts. On the other hand, isobologram based approach showed slight antagonism for the effects on RBC and WBC while no interactions were proved for the joint effect on PLT count. These results confirm that the assessment of interactions between chemicals in the mixture greatly depends on the concept or method used for this evaluation.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsrestrictedAccess
dc.sourceToxicology and Industrial Health
dc.titleInteractions between cadmium and decabrominated diphenyl ether on blood cells count in rats-Multiple factorial regression analysisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂукић-Ћосић, Данијела; Ћурчић, Маријана; Вуцнић, Славица; Aнтонијевић, Евица; Миловановић, Весна; Булат, Зорица; Матовић, Весна; Станковић, Сања; Буха, Aлександра; Aнтонијевић, Биљана;
dc.citation.volume376
dc.citation.spage120
dc.citation.epage125
dc.citation.other376: 120-125
dc.citation.rankM21
dc.identifier.wos000393526700015
dc.identifier.doi10.1016/j.tox.2016.05.011
dc.identifier.pmid27181932
dc.identifier.scopus2-s2.0-84969802820
dc.identifier.rcubconv_3758
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record