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Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers

Samo za registrovane korisnike
2017
Autori
Todosijević, Marija N.
Brezesinski, Gerald
Savić, Snežana
Neubert, Reinhard H. H.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
Up to now, the molecular mechanism of the penetration enhancing effect of sucrose esters (SEs) on stratum corneum (SC) has not been explained in details. In this study, variety of surface sensitive techniques, including surface pressure-area (pi-A) isotherms, infrared reflection-absorption spectroscopy (IRRAS), and Brewster angle microscopy (BAM), have been used to investigate interactions between SEs and SC intercellular lipids. A monolayer of the mixture of ceramide AS C18:18, stearic acid and cholesterol in the molar ratio of 1:1:0.7 on an aqueous subphase is a good model to mimic a single layer of intercellular SC lipids. The pi-A isotherms of mixed monolayers and parameters derived from the curves demonstrated the interaction between nonionic surfactants such as SEs and SC lipids. With increasing SE concentration, the resultant monolayer films became more fluid and better compressible. IRRAS measurements showed that SEs disordered the acyl chains of SC lipids, and the BAM images d...emonstrated the modification of the domain structures in SC monolayers. Longer chain-SE has a stronger disordering effect and is better miscible with ceramides in comparison to SE with a shorter hydrophobic part. In conclusion, this study demonstrates the disordering effect of SEs on the biomimetic SC model, pointing out that small changes in the structure of surfactant may have a strong influence on a penetration enhancement of lipophilic drugs through intercellular lipids of skin.

Izvor:
European Journal of Pharmaceutical Sciences, 2017, 99, 161-172
Izdavač:
  • Elsevier Science BV, Amsterdam
Projekti:
  • Razvoj mikro- i nanosistema kao nosača za lekove sa antiinflamatornim delovanjem i metoda za njihovu karakterizaciju (RS-34031)

DOI: 10.1016/j.ejps.2016.12.002

ISSN: 0928-0987

PubMed: 27940082

WoS: 000394474200017

Scopus: 2-s2.0-85007248196
[ Google Scholar ]
8
5
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2949
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy

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