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dc.creatorTodosijević, Marija N.
dc.creatorBrezesinski, Gerald
dc.creatorSavić, Snežana
dc.creatorNeubert, Reinhard H. H.
dc.date.accessioned2019-09-02T12:01:13Z
dc.date.available2019-09-02T12:01:13Z
dc.date.issued2017
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2949
dc.description.abstractUp to now, the molecular mechanism of the penetration enhancing effect of sucrose esters (SEs) on stratum corneum (SC) has not been explained in details. In this study, variety of surface sensitive techniques, including surface pressure-area (pi-A) isotherms, infrared reflection-absorption spectroscopy (IRRAS), and Brewster angle microscopy (BAM), have been used to investigate interactions between SEs and SC intercellular lipids. A monolayer of the mixture of ceramide AS C18:18, stearic acid and cholesterol in the molar ratio of 1:1:0.7 on an aqueous subphase is a good model to mimic a single layer of intercellular SC lipids. The pi-A isotherms of mixed monolayers and parameters derived from the curves demonstrated the interaction between nonionic surfactants such as SEs and SC lipids. With increasing SE concentration, the resultant monolayer films became more fluid and better compressible. IRRAS measurements showed that SEs disordered the acyl chains of SC lipids, and the BAM images demonstrated the modification of the domain structures in SC monolayers. Longer chain-SE has a stronger disordering effect and is better miscible with ceramides in comparison to SE with a shorter hydrophobic part. In conclusion, this study demonstrates the disordering effect of SEs on the biomimetic SC model, pointing out that small changes in the structure of surfactant may have a strong influence on a penetration enhancement of lipophilic drugs through intercellular lipids of skin.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.titleSucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавић, Снежана; Брезесински, Гералд; Неуберт, Реинхард Х. Х.; Тодосијевић, Марија Н.;
dc.citation.volume99
dc.citation.spage161
dc.citation.epage172
dc.citation.other99: 161-172
dc.citation.rankM21
dc.identifier.wos000394474200017
dc.identifier.doi10.1016/j.ejps.2016.12.002
dc.identifier.pmid27940082
dc.identifier.scopus2-s2.0-85007248196
dc.identifier.rcubconv_3769
dc.type.versionpublishedVersion


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