Show simple item record

dc.creatorMarinković, Valentina
dc.creatorAgbaba, Danica
dc.creatorVladimirov, S
dc.creatorStanković, S
dc.date.accessioned2019-09-02T10:53:26Z
dc.date.available2019-09-02T10:53:26Z
dc.date.issued2001
dc.identifier.issn0731-7085
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/294
dc.description.abstractA method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.titleSimultaneous HPLC determination of nitrendipine and impurities of the process of synthesisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВладимиров, С; Маринковић, Валентина; Aгбаба, Даница; Станковић, С;
dc.citation.volume24
dc.citation.issue5-6
dc.citation.spage993
dc.citation.epage998
dc.citation.other24(5-6): 993-998
dc.citation.rankM22
dc.identifier.wos000167764200028
dc.identifier.doi10.1016/S0731-7085(00)00531-8
dc.identifier.pmid11248493
dc.identifier.scopus2-s2.0-0035089540
dc.identifier.rcubconv_1301
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record