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A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation

Authorized Users Only
2001
Authors
Radulović, Dušanka
Karljiković-Rajić, Katarina
Lucić, BM
Vujić, Zorica
Article (Published version)
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Abstract
The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2001, 24, 5-6, 871-876
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/S0731-7085(00)00555-0

ISSN: 0731-7085

PubMed: 11248480

WoS: 000167764200015

Scopus: 2-s2.0-0035091312
[ Google Scholar ]
7
4
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/295
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Radulović, Dušanka
AU  - Karljiković-Rajić, Katarina
AU  - Lucić, BM
AU  - Vujić, Zorica
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/295
AB  - The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation
VL  - 24
IS  - 5-6
SP  - 871
EP  - 876
DO  - 10.1016/S0731-7085(00)00555-0
ER  - 
@article{
author = "Radulović, Dušanka and Karljiković-Rajić, Katarina and Lucić, BM and Vujić, Zorica",
year = "2001",
abstract = "The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation",
volume = "24",
number = "5-6",
pages = "871-876",
doi = "10.1016/S0731-7085(00)00555-0"
}
Radulović, D., Karljiković-Rajić, K., Lucić, B.,& Vujić, Z.. (2001). A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 871-876.
https://doi.org/10.1016/S0731-7085(00)00555-0
Radulović D, Karljiković-Rajić K, Lucić B, Vujić Z. A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. in Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):871-876.
doi:10.1016/S0731-7085(00)00555-0 .
Radulović, Dušanka, Karljiković-Rajić, Katarina, Lucić, BM, Vujić, Zorica, "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation" in Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):871-876,
https://doi.org/10.1016/S0731-7085(00)00555-0 . .

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