The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2001, 24, 5-6, 871-876
TY - JOUR
AU - Radulović, Dušanka
AU - Karljiković-Rajić, Katarina
AU - Lucić, BM
AU - Vujić, Zorica
PY - 2001
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/295
AB - The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Journal of Pharmaceutical and Biomedical Analysis
T1 - A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation
VL - 24
IS - 5-6
SP - 871
EP - 876
DO - 10.1016/S0731-7085(00)00555-0
ER -
@article{
author = "Radulović, Dušanka and Karljiković-Rajić, Katarina and Lucić, BM and Vujić, Zorica",
year = "2001",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/295",
abstract = "The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation",
volume = "24",
number = "5-6",
pages = "871-876",
doi = "10.1016/S0731-7085(00)00555-0"
}
Radulović, D., Karljiković-Rajić, K., Lucić, B.,& Vujić, Z. (2001). A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation.
Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 871-876.
https://doi.org/10.1016/S0731-7085(00)00555-0
Radulović D, Karljiković-Rajić K, Lucić B, Vujić Z. A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):871-876
Radulović Dušanka, Karljiković-Rajić Katarina, Lucić BM, Vujić Zorica, "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation" Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):871-876,
https://doi.org/10.1016/S0731-7085(00)00555-0 .
