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Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?

Само за регистроване кориснике
2017
Аутори
Gojković, Tamara
Vladimirov, Sandra
Spasojević-Kalimanovska, Vesna
Zeljković, Aleksandra
Vekić, Jelena
Kalimanovska-Oštrić, Dimitra
Đuričić, Ivana
Šobajić, Slađana
Jelić-Ivanović, Zorana
Чланак у часопису (Објављена верзија)
Метаподаци
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Апстракт
Background: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis... markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.

Извор:
Clinical Chemistry and Laboratory Medicine, 2017, 55, 3, 447-457
Издавач:
  • Walter de Gruyter Gmbh, Berlin
Пројекти:
  • Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-175035)

DOI: 10.1515/cclm-2016-0505

ISSN: 1434-6621

PubMed: 27718480

WoS: 000394145100027

Scopus: 2-s2.0-85012873033
[ Google Scholar ]
6
6
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2954
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

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