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dc.creatorGojković, Tamara
dc.creatorVladimirov, Sandra
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorZeljković, Aleksandra
dc.creatorVekić, Jelena
dc.creatorKalimanovska-Oštrić, Dimitra
dc.creatorĐuričić, Ivana
dc.creatorŠobajić, Slađana
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T12:01:20Z
dc.date.available2019-09-02T12:01:20Z
dc.date.issued2017
dc.identifier.issn1434-6621
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2954
dc.description.abstractBackground: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.en
dc.publisherWalter de Gruyter Gmbh, Berlin
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Chemistry and Laboratory Medicine
dc.titleCan non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГојковић, Тамара; Спасојевић-Калимановска, Весна; Ђуричић, Ивана; Јелић-Ивановић, Зорана; Шобајић, Слађана; Векић, Јелена; Владимиров, Сандра; Зељковић, Aлександра; Калимановска-Оштрић, Димитра;
dc.citation.volume55
dc.citation.issue3
dc.citation.spage447
dc.citation.epage457
dc.citation.other55(3): 447-457
dc.citation.rankM21
dc.identifier.wos000394145100027
dc.identifier.doi10.1515/cclm-2016-0505
dc.identifier.pmid27718480
dc.identifier.scopus2-s2.0-85012873033
dc.identifier.rcubconv_3763
dc.type.versionpublishedVersion


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