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dc.creatorMichalickova, Danica
dc.creatorKostić-Vučićević, Marija
dc.creatorVukašinović-Vesić, Milica
dc.creatorStojmenović, Tamara
dc.creatorDikić, Nenad
dc.creatorAnđelković, Marija
dc.creatorĐorđević, Brižita
dc.creatorTanasković, Bojana P.
dc.creatorMinić, Rajna
dc.date.accessioned2019-09-02T12:01:21Z
dc.date.available2019-09-02T12:01:21Z
dc.date.issued2017
dc.identifier.issn1064-8011
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2955
dc.description.abstractTo test the influence of probiotic supplementation on humoral immune response, a double-blind, placebo-controlled trial was conducted. Thirty athletes (24 males and 6 females, females: (V)over dotO(2)max 38.2 +/- 4.9 ml.kg(-1).min(-1), age 23.2 +/- 1.4 years; males: (V)over dotO(2)max 57.5 +/- 9.2 ml.kg(-1).min(-1), age 24.0 +/- 2.4 years, mean +/- SD) were randomized either to the probiotic group (Lactobacillus helveticus Lafti L10, 2 x 10(10) colony-forming units) or to the placebo group. Serum and saliva samples were collected at the baseline and after 14 weeks. Total and specific antibacterial antibody levels of IgM, IgG, and IgA classes were determined for different bacteria in the serum, and in saliva, total and specific antibacterial IgA levels were examined. Total IgM was elevated in both probiotic (18%, 15-20%; mean, 90% confidence interval; p = 0.02) and placebo group (35%, 22-47%; p = 0.02), without observed differences in changes between the groups. No significant changes in IgM levels specific for tested bacteria were found. Total IgG level was constant in both groups. A significant (16%, 22.8 to 35%, p = 0.04) reduction of anti-Enterococcus faecalis IgG was noted in the placebo group, in comparison with the probiotic group. There was a substantial decrease in total IgA level in the placebo group, when measured either in serum (15%, 12-18%, p = 0.04) or in saliva (35%, -1.4 to 53%, p = 0.03). Significantly reduced levels of serum anti-lactic acid bacteria IgA antibodies in the placebo group compared with the probiotic group were detected for Lactobacillus rhamnosus LA68 (24%, 5.8-42%, p = 0.02) and for L. rhamnosus LB64 (15%, 2.7-27%, p = 0.02). Probiotic administration could have beneficial effects on systemic humoral and mucosal immune responses.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Strength and Conditioning Research
dc.titleLactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trialen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМицхалицкова, Даница; Костић-Вучићевић, Марија; Вукашиновић-Весић, Милица; Стојменовић, Тамара; Aнђелковић, Марија; Ђорђевић, Брижита; Танасковић, Бојана П.; Дикић, Ненад; Минић, Рајна;
dc.citation.volume31
dc.citation.issue1
dc.citation.spage62
dc.citation.epage70
dc.citation.other31(1): 62-70
dc.citation.rankM22
dc.description.otherPeer-reviewed manuscript: [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3440]
dc.identifier.wos000391857900013
dc.identifier.doi10.1519/JSC.0000000000001456
dc.identifier.pmid27100317
dc.identifier.scopus2-s2.0-85017484618
dc.identifier.rcubconv_3737
dc.type.versionpublishedVersion


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