Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia
Само за регистроване кориснике
2017
Аутори
Vidović, BojanaMilovanović, Srđan
Stefanović, Aleksandra
Kotur-Stevuljević, Jelena
Takić, Marija
Debeljak-Martacić, Jasmina
Pantović, Maja
Đorđević, Brižita
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alphalipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may pla...y a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations.
Извор:
Journal of Medicinal Food, 2017, 20, 1, 79-85Издавач:
- Mary Ann Liebert, Inc, New Rochelle
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
- Развој и примена нових и традиционалних технологија у производњи конкурентних прехрамбених производа са додатом вредношћу за европско и светско тржиште - Створимо богатство из богатства Србије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
DOI: 10.1089/jmf.2016.0070
ISSN: 1096-620X
PubMed: 28009525
WoS: 000392117100010
Scopus: 2-s2.0-85010222315
Институција/група
PharmacyTY - JOUR AU - Vidović, Bojana AU - Milovanović, Srđan AU - Stefanović, Aleksandra AU - Kotur-Stevuljević, Jelena AU - Takić, Marija AU - Debeljak-Martacić, Jasmina AU - Pantović, Maja AU - Đorđević, Brižita PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2957 AB - Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alphalipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations. PB - Mary Ann Liebert, Inc, New Rochelle T2 - Journal of Medicinal Food T1 - Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia VL - 20 IS - 1 SP - 79 EP - 85 DO - 10.1089/jmf.2016.0070 ER -
@article{ author = "Vidović, Bojana and Milovanović, Srđan and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Takić, Marija and Debeljak-Martacić, Jasmina and Pantović, Maja and Đorđević, Brižita", year = "2017", abstract = "Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and anti-inflammatory properties and is suggested to be a biomarker of metabolic disturbances. The aim of this study was to investigate the effects of alphalipoic acid (ALA) on plasma adiponectin and some metabolic risk factors in patients with schizophrenia. The plasma adipokine levels (adiponectin and leptin), routine biochemical and anthropometric parameters, markers of oxidative stress, and the serum phospholipid fatty acid profile in eighteen schizophrenic patients at baseline, in the middle, and at the end of a 3-month long supplementation period with ALA (500 mg daily) were determined. A significant increase in the plasma adiponectin concentrations, as well as a decrease in fasting glucose and aspartate aminotransferase activity (AST), was found. Baseline AST activity was independently correlated with the adiponectin concentrations. Our data show that ALA can improve plasma adiponectin levels and may play a potential role in the treatment of metabolic risk factor in patients with schizophrenia. Future randomized controlled trials are needed to confirm these preliminary investigations.", publisher = "Mary Ann Liebert, Inc, New Rochelle", journal = "Journal of Medicinal Food", title = "Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia", volume = "20", number = "1", pages = "79-85", doi = "10.1089/jmf.2016.0070" }
Vidović, B., Milovanović, S., Stefanović, A., Kotur-Stevuljević, J., Takić, M., Debeljak-Martacić, J., Pantović, M.,& Đorđević, B.. (2017). Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia. in Journal of Medicinal Food Mary Ann Liebert, Inc, New Rochelle., 20(1), 79-85. https://doi.org/10.1089/jmf.2016.0070
Vidović B, Milovanović S, Stefanović A, Kotur-Stevuljević J, Takić M, Debeljak-Martacić J, Pantović M, Đorđević B. Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia. in Journal of Medicinal Food. 2017;20(1):79-85. doi:10.1089/jmf.2016.0070 .
Vidović, Bojana, Milovanović, Srđan, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Takić, Marija, Debeljak-Martacić, Jasmina, Pantović, Maja, Đorđević, Brižita, "Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients with Schizophrenia" in Journal of Medicinal Food, 20, no. 1 (2017):79-85, https://doi.org/10.1089/jmf.2016.0070 . .