Thymus dacicus as a new source of antioxidant and antimicrobial metabolites
Само за регистроване кориснике
2017
Аутори
Petrović, SilvanaUšjak, Ljuboš
Milenković, Marina
Arsenijević, Jelena
Drobac, Milica
Drndarević, Aneta
Niketić, Marjan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In a search for novel food additives functional food ingredients, chemical composition, and antioxidant and antimicrobial activities of Thymus dacicus Borbas (Lamiaceae) flowering aerial parts dry methanol extract and essential oil were tested for the first time. HPLC analysis of the extract revealed that among dominant polyphenols, rosmarinic acid was the most abundant (71.33 +/- 1.11 mg/g). Monoterpenes geranial (34.4%) and neral (23.9%) prevailed in the oil, analyzed by GC and GC-MS. The extract showed pronounced antioxidant activity, with FRAP value of 5.16 +/- 0.19 mmol Fe2+/g, OH radical SC50 of 18.85 µg/mL (determined by 2-deoxyribose assay) and DPPH radical SC50 of 28.04 µg/mL. Eight out of ten tested microbial strains were susceptible to the oil in microdilution test. Furthermore, for the combination of the oil and vancomycin/gentamicin, synergism was demonstrated against MRSA, Klebsiella pneumoniae and Escherichia coli in checkerboard test. Obtained results encourage further ...research of this herb as potentially beneficial ingredient in foodstuffs.
Извор:
Journal of Functional Foods, 2017, 28, 114-121Издавач:
- Elsevier Science BV, Amsterdam
Финансирање / пројекти:
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-Basic Research (BR or ON)-173021)
DOI: 10.1016/j.jff.2016.11.007
ISSN: 1756-4646
WoS: 000392885000014
Scopus: 2-s2.0-84998780318
Институција/група
PharmacyTY - JOUR AU - Petrović, Silvana AU - Ušjak, Ljuboš AU - Milenković, Marina AU - Arsenijević, Jelena AU - Drobac, Milica AU - Drndarević, Aneta AU - Niketić, Marjan PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2959 AB - In a search for novel food additives functional food ingredients, chemical composition, and antioxidant and antimicrobial activities of Thymus dacicus Borbas (Lamiaceae) flowering aerial parts dry methanol extract and essential oil were tested for the first time. HPLC analysis of the extract revealed that among dominant polyphenols, rosmarinic acid was the most abundant (71.33 +/- 1.11 mg/g). Monoterpenes geranial (34.4%) and neral (23.9%) prevailed in the oil, analyzed by GC and GC-MS. The extract showed pronounced antioxidant activity, with FRAP value of 5.16 +/- 0.19 mmol Fe2+/g, OH radical SC50 of 18.85 µg/mL (determined by 2-deoxyribose assay) and DPPH radical SC50 of 28.04 µg/mL. Eight out of ten tested microbial strains were susceptible to the oil in microdilution test. Furthermore, for the combination of the oil and vancomycin/gentamicin, synergism was demonstrated against MRSA, Klebsiella pneumoniae and Escherichia coli in checkerboard test. Obtained results encourage further research of this herb as potentially beneficial ingredient in foodstuffs. PB - Elsevier Science BV, Amsterdam T2 - Journal of Functional Foods T1 - Thymus dacicus as a new source of antioxidant and antimicrobial metabolites VL - 28 SP - 114 EP - 121 DO - 10.1016/j.jff.2016.11.007 ER -
@article{ author = "Petrović, Silvana and Ušjak, Ljuboš and Milenković, Marina and Arsenijević, Jelena and Drobac, Milica and Drndarević, Aneta and Niketić, Marjan", year = "2017", abstract = "In a search for novel food additives functional food ingredients, chemical composition, and antioxidant and antimicrobial activities of Thymus dacicus Borbas (Lamiaceae) flowering aerial parts dry methanol extract and essential oil were tested for the first time. HPLC analysis of the extract revealed that among dominant polyphenols, rosmarinic acid was the most abundant (71.33 +/- 1.11 mg/g). Monoterpenes geranial (34.4%) and neral (23.9%) prevailed in the oil, analyzed by GC and GC-MS. The extract showed pronounced antioxidant activity, with FRAP value of 5.16 +/- 0.19 mmol Fe2+/g, OH radical SC50 of 18.85 µg/mL (determined by 2-deoxyribose assay) and DPPH radical SC50 of 28.04 µg/mL. Eight out of ten tested microbial strains were susceptible to the oil in microdilution test. Furthermore, for the combination of the oil and vancomycin/gentamicin, synergism was demonstrated against MRSA, Klebsiella pneumoniae and Escherichia coli in checkerboard test. Obtained results encourage further research of this herb as potentially beneficial ingredient in foodstuffs.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Functional Foods", title = "Thymus dacicus as a new source of antioxidant and antimicrobial metabolites", volume = "28", pages = "114-121", doi = "10.1016/j.jff.2016.11.007" }
Petrović, S., Ušjak, L., Milenković, M., Arsenijević, J., Drobac, M., Drndarević, A.,& Niketić, M.. (2017). Thymus dacicus as a new source of antioxidant and antimicrobial metabolites. in Journal of Functional Foods Elsevier Science BV, Amsterdam., 28, 114-121. https://doi.org/10.1016/j.jff.2016.11.007
Petrović S, Ušjak L, Milenković M, Arsenijević J, Drobac M, Drndarević A, Niketić M. Thymus dacicus as a new source of antioxidant and antimicrobial metabolites. in Journal of Functional Foods. 2017;28:114-121. doi:10.1016/j.jff.2016.11.007 .
Petrović, Silvana, Ušjak, Ljuboš, Milenković, Marina, Arsenijević, Jelena, Drobac, Milica, Drndarević, Aneta, Niketić, Marjan, "Thymus dacicus as a new source of antioxidant and antimicrobial metabolites" in Journal of Functional Foods, 28 (2017):114-121, https://doi.org/10.1016/j.jff.2016.11.007 . .