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Thymus dacicus as a new source of antioxidant and antimicrobial metabolites

Authorized Users Only
2017
Authors
Petrović, Silvana
Ušjak, Ljuboš
Milenković, Marina
Arsenijević, Jelena
Drobac, Milica
Drndarević, Aneta
Niketić, Marjan
Article (Published version)
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Abstract
In a search for novel food additives functional food ingredients, chemical composition, and antioxidant and antimicrobial activities of Thymus dacicus Borbas (Lamiaceae) flowering aerial parts dry methanol extract and essential oil were tested for the first time. HPLC analysis of the extract revealed that among dominant polyphenols, rosmarinic acid was the most abundant (71.33 +/- 1.11 mg/g). Monoterpenes geranial (34.4%) and neral (23.9%) prevailed in the oil, analyzed by GC and GC-MS. The extract showed pronounced antioxidant activity, with FRAP value of 5.16 +/- 0.19 mmol Fe2+/g, OH radical SC50 of 18.85 µg/mL (determined by 2-deoxyribose assay) and DPPH radical SC50 of 28.04 µg/mL. Eight out of ten tested microbial strains were susceptible to the oil in microdilution test. Furthermore, for the combination of the oil and vancomycin/gentamicin, synergism was demonstrated against MRSA, Klebsiella pneumoniae and Escherichia coli in checkerboard test. Obtained results encourage further ...research of this herb as potentially beneficial ingredient in foodstuffs.

Source:
Journal of Functional Foods, 2017, 28, 114-121
Publisher:
  • Elsevier Science BV, Amsterdam
Funding / projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1016/j.jff.2016.11.007

ISSN: 1756-4646

WoS: 000392885000014

Scopus: 2-s2.0-84998780318
[ Google Scholar ]
27
23
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2959
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Petrović, Silvana
AU  - Ušjak, Ljuboš
AU  - Milenković, Marina
AU  - Arsenijević, Jelena
AU  - Drobac, Milica
AU  - Drndarević, Aneta
AU  - Niketić, Marjan
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2959
AB  - In a search for novel food additives functional food ingredients, chemical composition, and antioxidant and antimicrobial activities of Thymus dacicus Borbas (Lamiaceae) flowering aerial parts dry methanol extract and essential oil were tested for the first time. HPLC analysis of the extract revealed that among dominant polyphenols, rosmarinic acid was the most abundant (71.33 +/- 1.11 mg/g). Monoterpenes geranial (34.4%) and neral (23.9%) prevailed in the oil, analyzed by GC and GC-MS. The extract showed pronounced antioxidant activity, with FRAP value of 5.16 +/- 0.19 mmol Fe2+/g, OH radical SC50 of 18.85 µg/mL (determined by 2-deoxyribose assay) and DPPH radical SC50 of 28.04 µg/mL. Eight out of ten tested microbial strains were susceptible to the oil in microdilution test. Furthermore, for the combination of the oil and vancomycin/gentamicin, synergism was demonstrated against MRSA, Klebsiella pneumoniae and Escherichia coli in checkerboard test. Obtained results encourage further research of this herb as potentially beneficial ingredient in foodstuffs.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Functional Foods
T1  - Thymus dacicus as a new source of antioxidant and antimicrobial metabolites
VL  - 28
SP  - 114
EP  - 121
DO  - 10.1016/j.jff.2016.11.007
ER  - 
@article{
author = "Petrović, Silvana and Ušjak, Ljuboš and Milenković, Marina and Arsenijević, Jelena and Drobac, Milica and Drndarević, Aneta and Niketić, Marjan",
year = "2017",
abstract = "In a search for novel food additives functional food ingredients, chemical composition, and antioxidant and antimicrobial activities of Thymus dacicus Borbas (Lamiaceae) flowering aerial parts dry methanol extract and essential oil were tested for the first time. HPLC analysis of the extract revealed that among dominant polyphenols, rosmarinic acid was the most abundant (71.33 +/- 1.11 mg/g). Monoterpenes geranial (34.4%) and neral (23.9%) prevailed in the oil, analyzed by GC and GC-MS. The extract showed pronounced antioxidant activity, with FRAP value of 5.16 +/- 0.19 mmol Fe2+/g, OH radical SC50 of 18.85 µg/mL (determined by 2-deoxyribose assay) and DPPH radical SC50 of 28.04 µg/mL. Eight out of ten tested microbial strains were susceptible to the oil in microdilution test. Furthermore, for the combination of the oil and vancomycin/gentamicin, synergism was demonstrated against MRSA, Klebsiella pneumoniae and Escherichia coli in checkerboard test. Obtained results encourage further research of this herb as potentially beneficial ingredient in foodstuffs.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Functional Foods",
title = "Thymus dacicus as a new source of antioxidant and antimicrobial metabolites",
volume = "28",
pages = "114-121",
doi = "10.1016/j.jff.2016.11.007"
}
Petrović, S., Ušjak, L., Milenković, M., Arsenijević, J., Drobac, M., Drndarević, A.,& Niketić, M.. (2017). Thymus dacicus as a new source of antioxidant and antimicrobial metabolites. in Journal of Functional Foods
Elsevier Science BV, Amsterdam., 28, 114-121.
https://doi.org/10.1016/j.jff.2016.11.007
Petrović S, Ušjak L, Milenković M, Arsenijević J, Drobac M, Drndarević A, Niketić M. Thymus dacicus as a new source of antioxidant and antimicrobial metabolites. in Journal of Functional Foods. 2017;28:114-121.
doi:10.1016/j.jff.2016.11.007 .
Petrović, Silvana, Ušjak, Ljuboš, Milenković, Marina, Arsenijević, Jelena, Drobac, Milica, Drndarević, Aneta, Niketić, Marjan, "Thymus dacicus as a new source of antioxidant and antimicrobial metabolites" in Journal of Functional Foods, 28 (2017):114-121,
https://doi.org/10.1016/j.jff.2016.11.007 . .

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