A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation
Abstract
The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2001, 24, 5-6, 871-876Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/S0731-7085(00)00555-0
ISSN: 0731-7085
PubMed: 11248480
WoS: 000167764200015
Scopus: 2-s2.0-0035091312
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Institution/Community
PharmacyTY - JOUR AU - Radulović, Dušanka AU - Karljiković-Rajić, Katarina AU - Lucić, BM AU - Vujić, Zorica PY - 2001 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/295 AB - The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation VL - 24 IS - 5-6 SP - 871 EP - 876 DO - 10.1016/S0731-7085(00)00555-0 ER -
@article{ author = "Radulović, Dušanka and Karljiković-Rajić, Katarina and Lucić, BM and Vujić, Zorica", year = "2001", abstract = "The inclusion complex formation between Metoprolol tartarata (MeT) and beta -cyclodextrin (beta -CD) has been investigated using hyperchromic shift at lambda (max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 1:1 and 1:2. Preliminary data. on usage of MeT/beta -CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta (1)-blockers.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation", volume = "24", number = "5-6", pages = "871-876", doi = "10.1016/S0731-7085(00)00555-0" }
Radulović, D., Karljiković-Rajić, K., Lucić, B.,& Vujić, Z.. (2001). A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. in Journal of Pharmaceutical and Biomedical Analysis Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 871-876. https://doi.org/10.1016/S0731-7085(00)00555-0
Radulović D, Karljiković-Rajić K, Lucić B, Vujić Z. A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. in Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):871-876. doi:10.1016/S0731-7085(00)00555-0 .
Radulović, Dušanka, Karljiković-Rajić, Katarina, Lucić, BM, Vujić, Zorica, "A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation" in Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):871-876, https://doi.org/10.1016/S0731-7085(00)00555-0 . .