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Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines

Authorized Users Only
2017
Authors
Ljujić, Mila
Mijatović, Sanja
Bulatović, Mirna Z.
Mojic, Marija
Maksimović-Ivanić, Danijela
Radojković, Dragica
Topić, Aleksandra
Article (Published version)
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Abstract
Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance.
Source:
Pathology & Oncology Research, 2017, 23, 2, 335-343
Publisher:
  • Springer, Dordrecht
Projects:
  • Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-173013)

DOI: 10.1007/s12253-016-0104-3

ISSN: 1219-4956

PubMed: 27617337

WoS: 000399000200014

Scopus: 2-s2.0-85016626907
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2964
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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