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dc.creatorTomić, Maja
dc.creatorMicov, Ana
dc.creatorPecikoza, Uroš
dc.creatorStepanović-Petrović, Radica
dc.date.accessioned2019-09-02T12:01:35Z
dc.date.available2019-09-02T12:01:35Z
dc.date.issued2017
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2967
dc.description.abstractNonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used medications in the world. They act via inhibition of cyclooxygenase (COX) isoenzymes. The combined analgesic, anti-inflammatory, and antipyretic effects make NSAIDs especially useful for symptomatic relief of painful inflammatory conditions and fever. They are used for treating musculoskeletal disorders (chronic, like osteoarthritis and rheumatoid arthritis, and acute, like acute gout and injuries), headaches, dental and postoperative pain, and dysmenorrhea, and aspirin also for prevention of cardiovascular events. NSAIDs may cause serious gastrointestinal, cardiovascular, and renal adverse effects, which may be prevented by performing risk assessments for each patient, choosing a NSAID with low risk for the particular side effect, and limiting its dosage and treatment duration. Gastroprotective agents are recommended for gastroduodenal ulcers prevention. Topical NSAIDs application offers a possibility for minimization of all systemic NSAIDs side effects, as well as drug-drug interactions. Evidence supports topical NSAIDs use in hands and knees osteoarthritis, and probably also in acute musculoskeletal pain. They can cause local skin irritation. Modified-release oral preparations improve patient compliance, and are especially important for short-acting NSAIDs. Topical modified-release preparations could improve efficacy and tolerability of NSAIDs topical treatment, and patient compliance.en
dc.publisherElsevier Inc.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS//
dc.rightsrestrictedAccess
dc.sourceMicrosized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
dc.subjectAdverse effectsen
dc.subjectClinical usesen
dc.subjectInteractionsen
dc.subjectModified-release preparationsen
dc.subjectNonsteroidal anti-inflammatory drugs (NSAIDs)en
dc.titleClinical Uses of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Potential Benefits of NSAIDs Modified-Release Preparationsen
dc.typebookPart
dc.rights.licenseARR
dcterms.abstractТомић, Маја; Мицов, Aна; Степановић-Петровић, Радица; Пецикоза, Урош;
dc.citation.spage1
dc.citation.epage29
dc.citation.other: 1-29
dc.identifier.doi10.1016/B978-0-12-804017-1.00001-7
dc.identifier.scopus2-s2.0-85022196379
dc.identifier.rcubconv_4653
dc.type.versionpublishedVersion


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