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dc.creatorĐurić, Ana
dc.creatorBegić, Aida
dc.creatorGobeljić, Borko
dc.creatorPantelić, Ana
dc.creatorZebić, Goran
dc.creatorStevanović, Ivana
dc.creatorĐurđević, Dragan
dc.creatorNinković, Milica
dc.creatorProkić, Vera
dc.creatorStanojević, Ivan
dc.creatorVojvodić, Danilo
dc.creatorĐukić, Mirjana
dc.date.accessioned2019-09-02T12:01:40Z
dc.date.available2019-09-02T12:01:40Z
dc.date.issued2017
dc.identifier.issn0278-6915
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2969
dc.description.abstractThe aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C-21/C-42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A(1-21) groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A(21)+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol). The measured parameters in testes included metals: zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) and selenium (Se); as well as oxidative stress (OS) parameters: superoxide anion radical (O-2(center dot-)), glutathione reduced (GSH) and oxidized (GSSG), malondialdehyde (MDA), hydrogen peroxide (H2O2) decomposition and activities of total superoxide dismutase (tSOD), glutathione-Stransferase (GST) and glutathione reductase (GR). Metal status was changed in all experimental groups (Fe rose, Zn fell, while Cu increased in A(21)+DSF24-32 groups). Development of OS was demonstrated in A(1-21) groups, but not in DSF1-21 groups. In A(21)+DSF22-42 groups, OS was partially reduced compared to A groups (A(1-21)>MDA>C; A(1-21) lt GSH lt C). High metal-binding affinity of DSF/DDTC changes red-ox homeostasis in rat testes.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectAlcoholen
dc.subjectDisulfiramen
dc.subjectTesticular toxicityen
dc.subjectOxidative stressen
dc.subjectTransition metalsen
dc.titleSubacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂурић, Aна; Пантелић, Aна; Гобељић, Борко; Зебић, Горан; Стевановић, Ивана; Станојевић, Иван; Прокић, Вера; Нинковић, Милица; Бегић, Aида; Ђурђевић, Драган; Војводић, Данило; Ђукић, Мирјана;
dc.citation.volume105
dc.citation.spage44
dc.citation.epage51
dc.citation.other105: 44-51
dc.citation.rankaM21
dc.identifier.wos000403625000006
dc.identifier.doi10.1016/j.fct.2017.03.041
dc.identifier.pmid28344087
dc.identifier.scopus2-s2.0-85016426201
dc.type.versionpublishedVersion


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