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Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes
dc.creator | Đurić, Ana | |
dc.creator | Begić, Aida | |
dc.creator | Gobeljić, Borko | |
dc.creator | Pantelić, Ana | |
dc.creator | Zebić, Goran | |
dc.creator | Stevanović, Ivana | |
dc.creator | Đurđević, Dragan | |
dc.creator | Ninković, Milica | |
dc.creator | Prokić, Vera | |
dc.creator | Stanojević, Ivan | |
dc.creator | Vojvodić, Danilo | |
dc.creator | Đukić, Mirjana | |
dc.date.accessioned | 2019-09-02T12:01:40Z | |
dc.date.available | 2019-09-02T12:01:40Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2969 | |
dc.description.abstract | The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C-21/C-42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A(1-21) groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A(21)+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol). The measured parameters in testes included metals: zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) and selenium (Se); as well as oxidative stress (OS) parameters: superoxide anion radical (O-2(center dot-)), glutathione reduced (GSH) and oxidized (GSSG), malondialdehyde (MDA), hydrogen peroxide (H2O2) decomposition and activities of total superoxide dismutase (tSOD), glutathione-Stransferase (GST) and glutathione reductase (GR). Metal status was changed in all experimental groups (Fe rose, Zn fell, while Cu increased in A(21)+DSF24-32 groups). Development of OS was demonstrated in A(1-21) groups, but not in DSF1-21 groups. In A(21)+DSF22-42 groups, OS was partially reduced compared to A groups (A(1-21)>MDA>C; A(1-21) lt GSH lt C). High metal-binding affinity of DSF/DDTC changes red-ox homeostasis in rat testes. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS// | |
dc.rights | restrictedAccess | |
dc.source | Food and Chemical Toxicology | |
dc.subject | Alcohol | en |
dc.subject | Disulfiram | en |
dc.subject | Testicular toxicity | en |
dc.subject | Oxidative stress | en |
dc.subject | Transition metals | en |
dc.title | Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ђурић, Aна; Пантелић, Aна; Гобељић, Борко; Зебић, Горан; Стевановић, Ивана; Станојевић, Иван; Прокић, Вера; Нинковић, Милица; Бегић, Aида; Ђурђевић, Драган; Војводић, Данило; Ђукић, Мирјана; | |
dc.citation.volume | 105 | |
dc.citation.spage | 44 | |
dc.citation.epage | 51 | |
dc.citation.other | 105: 44-51 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000403625000006 | |
dc.identifier.doi | 10.1016/j.fct.2017.03.041 | |
dc.identifier.pmid | 28344087 | |
dc.identifier.scopus | 2-s2.0-85016426201 | |
dc.type.version | publishedVersion |