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dc.creatorRenieri, Elisavet A.
dc.creatorSfakianakis, Dimitris G.
dc.creatorAlegakis, Athanasios A.
dc.creatorSafenkova, Irina V.
dc.creatorBuha, Aleksandra
dc.creatorMatović, Vesna
dc.creatorTzardi, Maria
dc.creatorDzantiev, Boris B.
dc.creatorDivanach, Pascal
dc.creatorKentouri, Maroudio
dc.creatorTsatsakis, Aristidis
dc.date.accessioned2019-09-02T12:01:41Z
dc.date.available2019-09-02T12:01:41Z
dc.date.issued2017
dc.identifier.issn0013-9351
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2971
dc.description.abstractCadmium (Cd) has proved to be associated with numerous toxic effects in aquatic organisms via waterbome exposure. With a view to investigate Cd toxicity along a broad spectrum of exposures reaching from environmental to toxic, we employed adult zebrafish (Danio rerio) for an in vivo study. A number of 10 fish per tank were placed in 40 L tanks and were exposed for 30 days to 0.0, 5.0, 25, 50, 75, 100 and 1000 mu g Cd per liter. There were 2 tanks for each Cd exposure (duplicate experiment). Mortality was recorded daily, dead fish were collected and tissue samples were obtained for histologic observation, whereas remaining tissues were stored for Cd burden determination. Surviving fish were collected at the end of the experiment. Median overall survival (OS) in days was found to be 9.0, 11.0, 8.0 and 7.0 for 25 mu g/L, 50 mu g/L, 75 mu g/L and 100 mu g/L respectively, with all of them showing mortality greater than 50%. Remarkably, fish exposed to the highest Cd concentration (1000 mu g/L) survived the longest exhibiting a mean OS of 29.2 days. Cd determination in fish tissue was conducted with an in house ICP-MS method and levels ranged from 3.1 to 29.1 ng/mg. Log Cd tissue levels were significantly correlated with the log Cd exposure levels (r = 0.535, p lt 0.001). The highest Cd burden was determined for fish exposed to 1000 mu g Cd /L (mean = 12.2 ng/mg). Histopathology supported these results. Our findings disclose a deviation in toxic responses through the range of Cd concentrations, leading to nonlinear responses. These differentiated responses, could be linked to hormesis phenomena.en
dc.publisherAcademic Press Inc Elsevier Science, San Diego
dc.rightsrestrictedAccess
dc.sourceEnvironmental Research
dc.subjectCadmium toxicityen
dc.subjectZebrafish mortalityen
dc.subjectNonlinear responseen
dc.titleNonlinear responses to waterborne cadmium exposure in zebrafish. An in vivo studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAлегакис, Aтханасиос A.; Диванацх, Пасцал; Буха, Aлександра; Тзарди, Мариа; Матовић, Весна; Сфакианакис, Димитрис Г.; Кентоури, Мароудио; Сафенкова, Ирина В.; Дзантиев, Борис Б.; Тсатсакис, Aристидис; Рениери, Елисавет A.;
dc.citation.volume157
dc.citation.spage173
dc.citation.epage181
dc.citation.other157: 173-181
dc.citation.rankaM21
dc.identifier.wos000403524000022
dc.identifier.doi10.1016/j.envres.2017.05.021
dc.identifier.pmid28570961
dc.identifier.scopus2-s2.0-85019657128
dc.identifier.rcubconv_3876
dc.type.versionpublishedVersion


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