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Menopauza kao nezavisni prediktor povišenih vrednosti retinolvezujućeg proteina 4 u serumu

dc.creatorKlisić, Aleksandra
dc.creatorStanišić, Verica
dc.creatorJovanović, Milovan
dc.creatorKavarić, Nebojša
dc.creatorNinić, Ana
dc.date.accessioned2019-09-02T12:01:46Z
dc.date.available2019-09-02T12:01:46Z
dc.date.issued2017
dc.identifier.issn0350-2899
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2973
dc.description.abstractAim: Retinol-binding protein 4 (RBP4) is a novel adipokine closely related to insulin resistance. However, data on the influence of menopausal status on serum RBP4 are scarce. Therefore, the aim of the current study was to examine whether RBP4 levels are associated with menopausal status per se, independently of insulin resistance. Methods: A total of 30 premenopausal and 100 postmenopausal women non-treated with medications were included in the cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure (BP) were obtained. The homeostasis model assessment of insulin resistance (HOMA-IR) and estimated glomerular filtration rate (eGFR) were calculated. Results: Postmenopausal women displayed higher RBP4 and an unfavorable cardiometabolic profile, compared to premenopausal ones. Multiple linear regression analysis showed that in addition to high triglycerides level (beta=0.315; p=0.002), decreased eGFR (beta=-0.258; p=0.004) and high systolic BP (beta=0.418; p=0.028), menopause per se is an independent predictor of higher RBP4 levels (beta=0.240; p=0.016), (R2-adjusted=0.310; F=6,522; p lt 0.001). Conclusions: Serum RBP4 levels are dependent of menopausal status, which should be taken into account when examining the role of this adipokine in cardiometabolic diseases' occurrence.en
dc.description.abstractCilj: Retinol-vezujući protein 4 (RBP4) je novi adipokin, usko povezan sa insulinskom rezistencijom. Međutim, nema dovoljno podataka u literaturi o uticaju menopauze na vrednosti ovog proteina u serumu. Zato je cilj ove studije bio da se ispita da li je povezanost menopauze i RBP4 nezavisna ili je posredovana insulinskom rezistencijom. Metode: Ukupno 30 žena u premenopauzi i 100 žena u postmenopauzi, koje nisu na terapiji su uključene u studiju preseka. Mereni su antropometrijski i biohemijski parametri, kao i krvni pritisak (KP), HOMA indeksi, procenjena jačina glomerularne filtracije (JGF) i izračunati su. Rezultati: Kod žena u postmenopauzi zabeležene su veće vrednosti RBP4 i nepovoljniji kardiometabolički profil, u poređenju sa ženama u premenopauzi. Višestruka linearnaregresiona analiza je pokazala da su više vrednosti triglicerida (beta=0,315; p=0,002), smanjena JGF (beta=-0,258; p=0,004), više vrednosti sistolnog KP (beta=0,418; p=0,028), i menopauza (beta=0,240; p=0,016), nezavisni prediktori povišenih vrednosti RBP4 u serumu (R2-adjusted=0,310; F=6,522; p lt 0,001). Zaključak: Menopauza utiče na vrednosti RBP4 u serumu, što treba uzeti u obzir prilikom ispitivanja uloge ovog adipokina u pojavi kardiometaboličkih poremećaja.sr
dc.publisherSrpsko lekarsko društvo - Podružnica Zaječar, Zaječar
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceTimočki medicinski glasnik
dc.subjectadipokinesen
dc.subjectinsulin resistanceen
dc.subjectobesityen
dc.subjectpostmenopausalen
dc.subjectretinol-binding protein 4en
dc.subjectadipokinisr
dc.subjectinsulinska rezistencijasr
dc.subjectgojaznostsr
dc.subjectpostmenopauzasr
dc.subjectretinol-vezujući protein 4sr
dc.titleMenopausal status as an independent predictor of high serum retinol-binding protein 4 levelsen
dc.titleMenopauza kao nezavisni prediktor povišenih vrednosti retinolvezujućeg proteina 4 u serumusr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанишић, Верица; Каварић, Небојша; Јовановић, Милован; Нинић, Aна; Клисић, Aлександра; Менопауза као независни предиктор повишених вредности ретинолвезујућег протеина 4 у серуму; Менопауза као независни предиктор повишених вредности ретинолвезујућег протеина 4 у серуму;
dc.citation.volume42
dc.citation.issue4
dc.citation.spage199
dc.citation.epage205
dc.citation.other42(4): 199-205
dc.citation.rankM53
dc.identifier.doi10.5937/tmg1704199K
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1583/2971.pdf
dc.identifier.rcubconv_722
dc.type.versionpublishedVersion


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