ФарФаР - Фармацеутски факултет, репозиторијум
Универзитет у Београду, Фармацеутски факултет
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

Women with Polycystic Ovary Syndrome and Risk of Cardiovascular Disease

Thumbnail
2017
2985.pdf (626.6Kb)
Аутори
Perović-Blagojević, Iva
Eror, Tatjana
Pelivanović, Jovana
Jelić, Svetlana
Kotur-Stevuljević, Jelena
Ignjatović, Svetlana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
Background: Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk. Methods: Fifty-four young women with PCOS (22 obese and 32 normal weight) were compared to 46 respective controls (17 obese and 29 normal weight). Anthropometric parameters, lipid status parameters, inflammation markers, concentrations of glucose, transaminases, sex and anterior pituitary hormones, sex hormone binding globulin (SHBG) and androgens were measured. Cardiovascular Risk Score (CVRS), indices for identifying Non-Alcoholic Fatty Liver Disease (NAFLD) and the Index of Central Obesity (ICO) were calculated. Results: Significantly higher CVRS values (p lt 0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinog...en (p lt 0.001, p lt 0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLD indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC> 0.8) in identifying patients with increased cardiovascular risk (CVR). Conclusions: Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO.

Кључне речи:
polycystic ovary syndrome / cardiovascular disease / cardiovascular risk score / non-alcoholic fatty liver disease / central obesity index
Извор:
Journal of Medical Biochemistry, 2017, 36, 3, 259-269
Издавач:
  • Društvo medicinskih biohemičara Srbije, Beograd i Versita
Пројекти:
  • Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-175035)

DOI: 10.1515/jomb-2017-0020

ISSN: 1452-8258

PubMed: 30568543

WoS: 000405624000010

Scopus: 2-s2.0-85026822930
[ Google Scholar ]
14
13
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2987
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB
 

 

Комплетан репозиторијумИнституцијеАуториНасловиТемеОва институцијаАуториНасловиТеме

Статистика

Преглед статистика

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB