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Microemulsions and Nanoemulsions as Carriers for Delivery of NSAIDs

Authorized Users Only
2017
Authors
Đekić, Ljiljana
Primorac, Marija
Book part (Published version)
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Abstract
This chapter reviews current progress in development of microemulsion- and nanoemulsion-based drug delivery systems as carriers for nonsteroidal anti-inflammatory drugs (NSAIDs) which are members of class II active pharmaceutical ingredients according to the Biopharmaceutical Classification System (e.g., ibuprofen, diclofenac, ketoprofen, celecoxib, etodolac). Thermodynamical and physicochemical considerations on microemulsions and nanoemulsions are presented concisely. The main experimental approaches in design of microemulsion/nanoemulsion carriers as well as their preconcentrates (self-micro/nanoemulsifying systems) are described. The performances of the characterization techniques employed in evaluation of self-micro/nanoemulsification process and identification and differentiation of microemulsion/nanoemulsion carriers are commented. The potential advantages of NSAIDs encapsulation by using microemulsion/nanoemulsion carriers, including development of physically stable pharmaceuti...cal dosage form with high drug loading capacity, dispersibility, rate and extent of absorption, and thus increased bioavailability, are illustrated by observations and conclusions derived from the extensive results of the relevant studies in this field.

Keywords:
Droplet size analysis / Drug absorption / Drug release / Microemulsion / Nanoemulsion / NSAIDs / Oral drug delivery / Self-micro/nanoemulsification process / Self-micro/nanoemulsifying systems
Source:
Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a, 2017, 69-94
Publisher:
  • Elsevier Inc.

DOI: 10.1016/B978-0-12-804017-1.00003-0

Scopus: 2-s2.0-85022176210
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6
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2989
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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