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Enriched environment alters the behavioral profile of tenascin-C deficient mice

Authorized Users Only
2017
Authors
Stamenković, V.
Milenković, I.
Galjak, N.
Todorović, Vanja
Anđus, P.
Article (Published version)
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Abstract
Tenascin-C (TnC) is an extracellular matrix glycoprotein implicated in a variety of processes ranging from brain development to synaptic plasticity in the adult vertebrates. Although the role of the TnC gene in regulation of behavior has been investigated, it remained elusive how TnC deficiency interacts with the environment in shaping the behavioral phenotype. To address this, 3-week-old TnC+/+ and TnC-/- male mice were housed over an 8-week period in standard conditions (SC), or enriched environment (EE). A comprehensive battery of tests was used in behavioral phenotyping. When housed in SC, TnC-/- mice showed spontaneous nocturnal hyperactivity, as well as poor sensorimotor coordination and low swimming velocity. However, housing of TnC-/- mice in EE abolished hyperlocomotion, led to faster habituation to novel environment, strengthened the grasp of fore limbs and partially improved movement coordination, while the swimming ability remained deficient. Conversely, TnC deficiency atte...nuated both the beneficial effects of EE on learning/memory capacity and the anxiolytic effect of EE in reducing the level of acrophobia. This study expands the existing knowledge about the phenotype associated with TnC deficiency, and reveals that the effect of genetic background on the behavioral response could be altered by post-weaning housing in a highly stimulating environment.

Keywords:
Tenascin-C deficient mice / Enriched environment / Sensorimotor function / Spontaneous nocturnal activity / Emotional reactivity / Learning/memory capacity
Source:
Behavioural Brain Research, 2017, 331, 241-253
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Biomarkers in neurodegenerative and malignant processes (RS-41005)

DOI: 10.1016/j.bbr.2017.05.047

ISSN: 0166-4328

PubMed: 28549651

WoS: 000404815100030

Scopus: 2-s2.0-85019703846
[ Google Scholar ]
7
6
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2991
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Stamenković, V.
AU  - Milenković, I.
AU  - Galjak, N.
AU  - Todorović, Vanja
AU  - Anđus, P.
PY  - 2017
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/2991
AB  - Tenascin-C (TnC) is an extracellular matrix glycoprotein implicated in a variety of processes ranging from brain development to synaptic plasticity in the adult vertebrates. Although the role of the TnC gene in regulation of behavior has been investigated, it remained elusive how TnC deficiency interacts with the environment in shaping the behavioral phenotype. To address this, 3-week-old TnC+/+ and TnC-/- male mice were housed over an 8-week period in standard conditions (SC), or enriched environment (EE). A comprehensive battery of tests was used in behavioral phenotyping. When housed in SC, TnC-/- mice showed spontaneous nocturnal hyperactivity, as well as poor sensorimotor coordination and low swimming velocity. However, housing of TnC-/- mice in EE abolished hyperlocomotion, led to faster habituation to novel environment, strengthened the grasp of fore limbs and partially improved movement coordination, while the swimming ability remained deficient. Conversely, TnC deficiency attenuated both the beneficial effects of EE on learning/memory capacity and the anxiolytic effect of EE in reducing the level of acrophobia. This study expands the existing knowledge about the phenotype associated with TnC deficiency, and reveals that the effect of genetic background on the behavioral response could be altered by post-weaning housing in a highly stimulating environment.
PB  - Elsevier Science BV, Amsterdam
T2  - Behavioural Brain Research
T1  - Enriched environment alters the behavioral profile of tenascin-C deficient mice
VL  - 331
SP  - 241
EP  - 253
DO  - 10.1016/j.bbr.2017.05.047
ER  - 
@article{
author = "Stamenković, V. and Milenković, I. and Galjak, N. and Todorović, Vanja and Anđus, P.",
year = "2017",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/2991",
abstract = "Tenascin-C (TnC) is an extracellular matrix glycoprotein implicated in a variety of processes ranging from brain development to synaptic plasticity in the adult vertebrates. Although the role of the TnC gene in regulation of behavior has been investigated, it remained elusive how TnC deficiency interacts with the environment in shaping the behavioral phenotype. To address this, 3-week-old TnC+/+ and TnC-/- male mice were housed over an 8-week period in standard conditions (SC), or enriched environment (EE). A comprehensive battery of tests was used in behavioral phenotyping. When housed in SC, TnC-/- mice showed spontaneous nocturnal hyperactivity, as well as poor sensorimotor coordination and low swimming velocity. However, housing of TnC-/- mice in EE abolished hyperlocomotion, led to faster habituation to novel environment, strengthened the grasp of fore limbs and partially improved movement coordination, while the swimming ability remained deficient. Conversely, TnC deficiency attenuated both the beneficial effects of EE on learning/memory capacity and the anxiolytic effect of EE in reducing the level of acrophobia. This study expands the existing knowledge about the phenotype associated with TnC deficiency, and reveals that the effect of genetic background on the behavioral response could be altered by post-weaning housing in a highly stimulating environment.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Behavioural Brain Research",
title = "Enriched environment alters the behavioral profile of tenascin-C deficient mice",
volume = "331",
pages = "241-253",
doi = "10.1016/j.bbr.2017.05.047"
}
Stamenković V, Milenković I, Galjak N, Todorović V, Anđus P. Enriched environment alters the behavioral profile of tenascin-C deficient mice. Behavioural Brain Research. 2017;331:241-253
Stamenković, V., Milenković, I., Galjak, N., Todorović, V.,& Anđus, P. (2017). Enriched environment alters the behavioral profile of tenascin-C deficient mice.
Behavioural Brain ResearchElsevier Science BV, Amsterdam., 331, 241-253.
https://doi.org/10.1016/j.bbr.2017.05.047
Stamenković V., Milenković I., Galjak N., Todorović Vanja, Anđus P., "Enriched environment alters the behavioral profile of tenascin-C deficient mice" 331 (2017):241-253,
https://doi.org/10.1016/j.bbr.2017.05.047 .

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