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dc.creatorBošnjak-Neumueller, Jasna
dc.creatorRadaković, Milena
dc.creatorĐelić, Ninoslav
dc.creatorVuković-Gacić, Branka
dc.creatorDajić-Stevanović, Zora
dc.creatorKolarević, Stoimir
dc.creatorMisić, Danijela
dc.creatorStanković, Milan
dc.creatorKnezević-Vukcević, Jelena
dc.creatorPotparević, Biljana
dc.creatorStanimirović, Zoran
dc.date.accessioned2019-09-02T12:02:13Z
dc.date.available2019-09-02T12:02:13Z
dc.date.issued2017
dc.identifier.issn1011-601X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2994
dc.description.abstractThe success of antioxidant therapy in hyperthyroidism implies that disease is mediated by oxidative stress, which is known as one of the causing agents of agemg, degenerative diseases, and cancer. The main objective of our study was to determine possible protective effects of methanolic extract of N. rtanjensis in triiodothyronine (T-3)-induced DNA breaks of human lymphocytes under in vitro conditions, based upon plant antioxidant capacity related to its phytochemical profile, mainly its polyphenolic complex. The total phenolic and flavonoid content and the antioxidant activity using in vitro 1,1-dyphenyl-2-picrylhydrazyl reagent (DPPH) was determined in methanolic extracts of plant leaves and flowers. The phenolic compound content of 62.73 +/- 1.80 mg of GaA/g, exhibited solid antioxidant activity (IC50= 112.59 +/- 0.95 g/ml). The antigenotoxic activity of 0.2, 0.5 and 1.0 mg/ml N. rtanjensis methanol extracts mixture with 100 mu M of T-3 was studied in human lymphocytes in vitro using the Comet assay. It is supposed that the antigenotoxicity of N. rtanjensis methanol extracts was caused by high presence of chlorogenic acid, rosmarinic acid and rutin, all known as efficient antioxidant bioactive compounds, which were determined by ultrahigh-pressure liquid chromatograph with MS/MS Mass Spectroscopy (UHPLC/-HESI-MS/MS).en
dc.publisherUniv Karachi, Karachi
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.rightsrestrictedAccess
dc.sourcePakistan journal of pharmaceutical sciences
dc.subjecttriiodothyronine
dc.subjectDNA damage
dc.subjectNepeta rtanjensis
dc.subjectphenolic compounds and antigenotoxic activity
dc.titleNepeta rtanjensis (Lamiaceae), a plant endemic to the Balkans: Phenolic composition antioxidant activity, and in vitro antigenotoxic effects in triiodothyronine-induced DNA damage in human lymphocytesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМисић, Данијела; Коларевић, Стоимир; Вуковић-Гацић, Бранка; Радаковић, Милена; Дајић-Стевановић, Зора; Станимировић, Зоран; Босњак-Неумуеллер, Јасна; Потпаревић, Биљана; Кнезевић-Вукцевић, Јелена; Ђелић, Нинослав; Станковић, Милан;
dc.citation.volume30
dc.citation.issue2
dc.citation.spage625
dc.citation.epage634
dc.citation.other30(2): 625-634
dc.citation.rankM23
dc.identifier.wos000404692500013
dc.identifier.pmid28650332
dc.identifier.scopus2-s2.0-85051631401
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_agrospace_4504
dc.type.versionpublishedVersion


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