Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine
Authorized Users Only
2017
Authors
Krstić, Marko
Đuriš, Jelena

Petrović, Ognjen
Lazarević, Nenad
Cvijić, Sandra

Ibrić, Svetlana

Article (Published version)

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The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutical...ly active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.
Keywords:
Carbamazepine / Lipid matrix tablets / Neusilin (R) UFL2 / Immediate release tablets / Melt granulation / Experimental designSource:
Journal of Drug Delivery Science and Technology, 2017, 39, 467-474Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.jddst.2017.04.024
ISSN: 1773-2247
WoS: 000404312200052
Scopus: 2-s2.0-85019193538
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PharmacyTY - JOUR AU - Krstić, Marko AU - Đuriš, Jelena AU - Petrović, Ognjen AU - Lazarević, Nenad AU - Cvijić, Sandra AU - Ibrić, Svetlana PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2995 AB - The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutically active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug. PB - Elsevier Science BV, Amsterdam T2 - Journal of Drug Delivery Science and Technology T1 - Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine VL - 39 SP - 467 EP - 474 DO - 10.1016/j.jddst.2017.04.024 ER -
@article{ author = "Krstić, Marko and Đuriš, Jelena and Petrović, Ognjen and Lazarević, Nenad and Cvijić, Sandra and Ibrić, Svetlana", year = "2017", abstract = "The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutically active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Drug Delivery Science and Technology", title = "Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine", volume = "39", pages = "467-474", doi = "10.1016/j.jddst.2017.04.024" }
Krstić, M., Đuriš, J., Petrović, O., Lazarević, N., Cvijić, S.,& Ibrić, S.. (2017). Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine. in Journal of Drug Delivery Science and Technology Elsevier Science BV, Amsterdam., 39, 467-474. https://doi.org/10.1016/j.jddst.2017.04.024
Krstić M, Đuriš J, Petrović O, Lazarević N, Cvijić S, Ibrić S. Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine. in Journal of Drug Delivery Science and Technology. 2017;39:467-474. doi:10.1016/j.jddst.2017.04.024 .
Krstić, Marko, Đuriš, Jelena, Petrović, Ognjen, Lazarević, Nenad, Cvijić, Sandra, Ibrić, Svetlana, "Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine" in Journal of Drug Delivery Science and Technology, 39 (2017):467-474, https://doi.org/10.1016/j.jddst.2017.04.024 . .