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Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine

Authorized Users Only
2017
Authors
Krstić, Marko
Đuriš, Jelena
Petrović, Ognjen
Lazarević, Nenad
Cvijić, Sandra
Ibrić, Svetlana
Article (Published version)
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Abstract
The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutical...ly active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.

Keywords:
Carbamazepine / Lipid matrix tablets / Neusilin (R) UFL2 / Immediate release tablets / Melt granulation / Experimental design
Source:
Journal of Drug Delivery Science and Technology, 2017, 39, 467-474
Publisher:
  • Elsevier Science BV, Amsterdam
Funding / projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.1016/j.jddst.2017.04.024

ISSN: 1773-2247

WoS: 000404312200052

Scopus: 2-s2.0-85019193538
[ Google Scholar ]
14
10
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2995
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Krstić, Marko
AU  - Đuriš, Jelena
AU  - Petrović, Ognjen
AU  - Lazarević, Nenad
AU  - Cvijić, Sandra
AU  - Ibrić, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2995
AB  - The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutically active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine
VL  - 39
SP  - 467
EP  - 474
DO  - 10.1016/j.jddst.2017.04.024
ER  - 
@article{
author = "Krstić, Marko and Đuriš, Jelena and Petrović, Ognjen and Lazarević, Nenad and Cvijić, Sandra and Ibrić, Svetlana",
year = "2017",
abstract = "The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutically active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine",
volume = "39",
pages = "467-474",
doi = "10.1016/j.jddst.2017.04.024"
}
Krstić, M., Đuriš, J., Petrović, O., Lazarević, N., Cvijić, S.,& Ibrić, S.. (2017). Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 39, 467-474.
https://doi.org/10.1016/j.jddst.2017.04.024
Krstić M, Đuriš J, Petrović O, Lazarević N, Cvijić S, Ibrić S. Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine. in Journal of Drug Delivery Science and Technology. 2017;39:467-474.
doi:10.1016/j.jddst.2017.04.024 .
Krstić, Marko, Đuriš, Jelena, Petrović, Ognjen, Lazarević, Nenad, Cvijić, Sandra, Ibrić, Svetlana, "Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine" in Journal of Drug Delivery Science and Technology, 39 (2017):467-474,
https://doi.org/10.1016/j.jddst.2017.04.024 . .

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