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dc.creatorKrstić, Marko
dc.creatorĐuriš, Jelena
dc.creatorPetrović, Ognjen
dc.creatorLazarević, Nenad
dc.creatorCvijić, Sandra
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T12:02:14Z
dc.date.available2019-09-02T12:02:14Z
dc.date.issued2017
dc.identifier.issn1773-2247
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2995
dc.description.abstractThe aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutically active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Drug Delivery Science and Technology
dc.subjectCarbamazepineen
dc.subjectLipid matrix tabletsen
dc.subjectNeusilin (R) UFL2en
dc.subjectImmediate release tabletsen
dc.subjectMelt granulationen
dc.subjectExperimental designen
dc.titleApplication of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦвијић, Сандра; Лазаревић, Ненад; Ђуриш, Јелена; Ибрић, Светлана; Петровић, Огњен; Крстић, Марко;
dc.citation.volume39
dc.citation.spage467
dc.citation.epage474
dc.citation.other39: 467-474
dc.citation.rankM22
dc.identifier.wos000404312200052
dc.identifier.doi10.1016/j.jddst.2017.04.024
dc.identifier.scopus2-s2.0-85019193538
dc.identifier.rcubconv_3886
dc.type.versionpublishedVersion


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