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dc.creatorMirković, Dušica
dc.creatorIbrić, Svetlana
dc.creatorBalanc, Bojana
dc.creatorKnez, Željko
dc.creatorBugarski, Branko
dc.date.accessioned2019-09-02T12:02:15Z
dc.date.available2019-09-02T12:02:15Z
dc.date.issued2017
dc.identifier.issn1773-2247
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2996
dc.description.abstractThe aim of this study was to develop, characterize and evaluate concentrated nanoemulsions (20%) for parenteral nutrition. Those systems were developed by the high-pressure homogenization method. Optimal conditions for the nanoemulsion production were identified using 2(4-1) fractional factorial design. The characterization of physicochemical parameters was carried out immediately after the nanoemulsion production, and after 10 and 30 days. The biological control was conducted 30 days after their preparation as well. The oil phase contained the combination of the soybean (SO) and fish oil (FO) as well as the fish oil and medium-chain triglycerides (MCT), while the aqueous phase was composed of water for injections. The egg yolk phospholipids (EP) were used as surfactants alone, or in combination with Poloxamer 188 (PI). The obtained results were in accordance with the literature date e.i. quality requirements for parenteral emulsions (the droplet diameter lt = 500 nm, PDI lt = 0.25, absolute value of zeta-potential >= 25 mV, pH-value in the range of 6-9). It was shown that the combination of two surfactants (the egg yolk phospholipids that provides the electrostatic stabilization and Poloxamer 188-steric stabilizer) used as emulsifiers ensures the optimal quality of the obtained nanoemulsions for parenteral nutrition.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Drug Delivery Science and Technology
dc.subjectNanoemulsionsen
dc.subjectParenteral nutritionen
dc.subjectStabilityen
dc.subjectPolydispersity indexen
dc.subjectFractional factorial designen
dc.titleEvaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsionsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИбрић, Светлана; Баланц, Бојана; Кнез, Жељко; Мирковић, Душица; Бугарски, Бранко;
dc.citation.volume39
dc.citation.spage341
dc.citation.epage347
dc.citation.other39: 341-347
dc.citation.rankM22
dc.identifier.wos000404312200037
dc.identifier.doi10.1016/j.jddst.2017.04.004
dc.identifier.scopus2-s2.0-85018486670
dc.identifier.rcubconv_3885
dc.type.versionpublishedVersion


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