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Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs- Practical Formulation Approach, Physicochemical and Biopharmaceutical Characteristics/Performances

Authorized Users Only
2017
Authors
Isailović, Tanja
Todosijević, Marija N.
Đorđević, Sanela
Savić, Snežana
Book part (Published version)
Metadata
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Abstract
Considering the superior advantages over traditional formulation approaches, micro/nanoemulsions represent very attractive carriers worth exploring for improving dermal/transdermal delivery of NSAIDs. Currently, natural-origin sucrose esters are of increasing interest for research community, due to their high environmental compatibility, low skin sensitization potential, and skin penetration enhancement. In this context, the present chapter provides an overview of sucrose esters' potential in the development of biocompatible micro/nanoemulsions for topical administration of NSAIDs. The formation and performances of sucrose ester-based micro/nanoemulsions are governed by numerous factors which should be carefully considered, such as (1) chain length and monoester content of the sucrose esters, (2) nature and concentration of the cosurfactant, oil, and aqueous phase, (3) the components' weight ratio, and (4) physicochemical characteristics of NSAID. Therefore, here we review the key rese...arches regarding NSAID-loaded sucrose ester-based micro/nanoemulsions, starting from the formulation design consideration, through physicochemical characterization and dermal/transdermal availability assessment of developed systems.

Keywords:
Dermal/transdermal availability / Imaging / Lecithin / Microemulsion / Nanoemulsion / NSAID / Physicochemical characterization / Sucrose ester
Source:
Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a, 2017, 179-217
Publisher:
  • Elsevier Inc.
Projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)

DOI: 10.1016/B978-0-12-804017-1.00007-8

Scopus: 2-s2.0-85022186904
[ Google Scholar ]
5
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2997
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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