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Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates

Authorized Users Only
2017
Authors
Ivanišević, Jasmina
Kotur-Stevuljević, Jelena
Stefanović, Aleksandra
Miljković, Milica
Jelić-Ivanović, Zorana
Pejović, Biljana
Peco-Antić, Amira
Article (Published version)
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Abstract
Objectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased ...PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.

Keywords:
Neonate / Asphyxia / Acute kidney injury / Paraoxonase 1 / Oxidative stress
Source:
Chemico-Biological Interactions, 2017, 272, 47-52
Publisher:
  • Elsevier Ireland Ltd, Clare
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1016/j.cbi.2017.04.014

ISSN: 0009-2797

PubMed: 28435017

WoS: 000404198300006

Scopus: 2-s2.0-85019188857
[ Google Scholar ]
8
4
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2998
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Miljković, Milica
AU  - Jelić-Ivanović, Zorana
AU  - Pejović, Biljana
AU  - Peco-Antić, Amira
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2998
AB  - Objectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates
VL  - 272
SP  - 47
EP  - 52
DO  - 10.1016/j.cbi.2017.04.014
ER  - 
@article{
author = "Ivanišević, Jasmina and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Miljković, Milica and Jelić-Ivanović, Zorana and Pejović, Biljana and Peco-Antić, Amira",
year = "2017",
abstract = "Objectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates",
volume = "272",
pages = "47-52",
doi = "10.1016/j.cbi.2017.04.014"
}
Ivanišević, J., Kotur-Stevuljević, J., Stefanović, A., Miljković, M., Jelić-Ivanović, Z., Pejović, B.,& Peco-Antić, A.. (2017). Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 272, 47-52.
https://doi.org/10.1016/j.cbi.2017.04.014
Ivanišević J, Kotur-Stevuljević J, Stefanović A, Miljković M, Jelić-Ivanović Z, Pejović B, Peco-Antić A. Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates. in Chemico-Biological Interactions. 2017;272:47-52.
doi:10.1016/j.cbi.2017.04.014 .
Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Miljković, Milica, Jelić-Ivanović, Zorana, Pejović, Biljana, Peco-Antić, Amira, "Association of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonates" in Chemico-Biological Interactions, 272 (2017):47-52,
https://doi.org/10.1016/j.cbi.2017.04.014 . .

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