Show simple item record

dc.creatorIvanišević, Jasmina
dc.creatorKotur-Stevuljević, Jelena
dc.creatorStefanović, Aleksandra
dc.creatorMiljković, Milica
dc.creatorJelić-Ivanović, Zorana
dc.creatorPejović, Biljana
dc.creatorPeco-Antić, Amira
dc.date.accessioned2019-09-02T12:02:19Z
dc.date.available2019-09-02T12:02:19Z
dc.date.issued2017
dc.identifier.issn0009-2797
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2998
dc.description.abstractObjectives: Acute kidney injury (AKI) is defined as a decrease in glomerular filtration rate with an increase in serum creatinine (sCr). Perinatal asphyxia (PNA) may be etiological factor for AKI with oxidative stress also implicated. Paraoxonase 1 (PON1) activity has been reported to be decreased in renal disease. The aim of our study was to evaluate paraoxonase 1 (PON1) activity and oxidative stress during the first hours and first days of life and to determine if these parameters could discriminate neonates having AKI from those who do not. Methods: Serum samples at different time points after birth were obtained from 64 preterm newborns with PNA (45 defined as having AKI, 19 as non-AKI). Clinical markers, sCr, total oxidant status (TOS), total antioxidant status (TAS) and PON1 activity were measured. Results: The AKI group had more newborns with hypoxic ischemic encephalopathy, significantly higher serum creatinine (sCr) at 3 and 7d, total antioxidant status (TAS) at 7d; decreased PON1 at 4h, 6h and 7d than the non-AKI group. Within the AKI group, significant positive correlations were found between PON1 activity at 2h and TAS at 2h, PON1 activity at 4h and base deficit (BD); whereas negative correlations between PON1 activity at 2h and AsCr (at 24h and at 3d), PON1 activity at 7d and AsCr (at 24h and 3d). Oxidative stress status parameters indicated excellent discriminative potential at 4h, 6h and 7d. Conclusions: AKI neonates were characterised by a marked decrease in PON1 activity. PON1 activity may be an important factor for discrimination of newborns having AKI from those that do not.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceChemico-Biological Interactions
dc.subjectNeonateen
dc.subjectAsphyxiaen
dc.subjectAcute kidney injuryen
dc.subjectParaoxonase 1en
dc.subjectOxidative stressen
dc.titleAssociation of paraoxonase 1 and oxidative stress with acute kidney injury in premature asphyxiated neonatesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиљковић, Милица; Јелић-Ивановић, Зорана; Котур-Стевуљевић, Јелена; Иванишевић, Јасмина; Стефановић, Aлександра; Пејовић, Биљана; Пецо-Aнтић, Aмира;
dc.citation.volume272
dc.citation.spage47
dc.citation.epage52
dc.citation.other272: 47-52
dc.citation.rankM21
dc.identifier.wos000404198300006
dc.identifier.doi10.1016/j.cbi.2017.04.014
dc.identifier.pmid28435017
dc.identifier.scopus2-s2.0-85019188857
dc.identifier.rcubconv_3883
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record