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dc.creatorFilipić, Brankica
dc.creatorMalesević, Milka
dc.creatorVasiljević, Zorica
dc.creatorLukić, Jovanka
dc.creatorNovović, Katarina
dc.creatorKojić, Milan
dc.creatorJovčić, Branko
dc.date.accessioned2019-09-02T12:02:20Z
dc.date.available2019-09-02T12:02:20Z
dc.date.issued2017
dc.identifier.issn2235-2988
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2999
dc.description.abstractAchromobacter spp. are recognized as emerging pathogens in hospitalized as well as in cystic fibrosis (CF) patients. From 2012 to 2015, we collected 69 clinical isolates (41 patient) of Achromobacter spp. from 13 patients with CF (CF isolates, n = 32) and 28 patients receiving care for other health conditions (non-CF isolates, n = 37). Molecular epidemiology and virulence potential of isolates were examined. Antimicrobial susceptibility, motility, ability to form biofilms and binding affinity to mucin, collagen, and fibronectin were tested to assess their virulence traits. The nrdA gene sequencing showed that A. xylosoxidans was the most prevalent species in both CF and non-CF patients. CF patients were also colonized with A. dolens/A, ruhlandii, A. insuavis, and A. spiritinus strains while non-CF group was somewhat less heterogenous, although A. insuavis, A. insolitus, and A. piechaudii strains were detected beside A. xylosoxidans. Three strains displayed clonal distribution, one among patients from the CF group and two among non-CF patients. No significant differences in susceptibility to antimicrobials were observed between CF and non-CF patients. About one third of the isolates were classified as strong biofilm producers, and the proportion of CF and non-CF isolates with the ability to form biofilm was almost identical. CF isolates were less motile compared to the non-CF group and no correlation was found between swimming phenotype and biofilm formation. On the other hand, CF isolates exhibited higher affinity to bind mucin, collagen, and fibronectin. In generall, CF isolates from our study exhibited in vitro properties that could be of importance for the colonization of CF patients.en
dc.publisherFrontiers Media Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173019/RS//
dc.rightsopenAccess
dc.sourceFrontiers in Cellular and Infection Microbiology
dc.titleUncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Originen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЈовчић, Бранко; Којић, Милан; Нововић, Катарина; Малесевић, Милка; Лукић, Јованка; Филипић, Бранкица; Васиљевић, Зорица;
dc.citation.volume7
dc.citation.other7: -
dc.citation.rankM22
dc.identifier.wos000402107300001
dc.identifier.doi10.3389/fcimb.2017.00224
dc.identifier.pmid28611955
dc.identifier.scopus2-s2.0-85027517077
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1606/2997.pdf
dc.identifier.rcubconv_3857
dc.type.versionpublishedVersion


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