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Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

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2017
3001.pdf (312.5Kb)
Authors
Bulat, Zorica
Đukić-Ćosić, Danijela
Antonijević, Biljana
Buha, Aleksandra
Bulat, Petar
Pavlović, Zoran
Matović, Vesna
Article (Published version)
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Abstract
The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10mg kg(-1) bw, as aqueous solution of Cd-chloride), and a Cd+ Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg(-1) bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4: 1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were ob...served in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn,Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.

Source:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2017, 68, 1, 38-45
Publisher:
  • Inst Medical Research & Occupational Health, Zagreb
Projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)

DOI: 10.1515/aiht-2017-68-2919

ISSN: 0004-1254

PubMed: 28365673

WoS: 000399013400005

Scopus: 2-s2.0-85017379859
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3003
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Pharmacy

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