The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10mg kg(-1) bw, as aqueous solution of Cd-chloride), and a Cd+ Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg(-1) bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4: 1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were ob...served in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn,Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.
Source:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2017, 68, 1, 38-45
Publisher:
Inst Medical Research & Occupational Health, Zagreb
TY - JOUR
AU - Bulat, Zorica
AU - Đukić-Ćosić, Danijela
AU - Antonijević, Biljana
AU - Buha, Aleksandra
AU - Bulat, Petar
AU - Pavlović, Zoran
AU - Matović, Vesna
PY - 2017
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3003
AB - The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10mg kg(-1) bw, as aqueous solution of Cd-chloride), and a Cd+ Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg(-1) bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4: 1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn,Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.
PB - Inst Medical Research & Occupational Health, Zagreb
T2 - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1 - Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?
VL - 68
IS - 1
SP - 38
EP - 45
DO - 10.1515/aiht-2017-68-2919
ER -
@article{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Antonijević, Biljana and Buha, Aleksandra and Bulat, Petar and Pavlović, Zoran and Matović, Vesna",
year = "2017",
abstract = "The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10mg kg(-1) bw, as aqueous solution of Cd-chloride), and a Cd+ Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg(-1) bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4: 1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn,Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?",
volume = "68",
number = "1",
pages = "38-45",
doi = "10.1515/aiht-2017-68-2919"
}
Bulat, Z., Đukić-Ćosić, D., Antonijević, B., Buha, A., Bulat, P., Pavlović, Z.,& Matović, V.. (2017). Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 68(1), 38-45.
https://doi.org/10.1515/aiht-2017-68-2919
Bulat Z, Đukić-Ćosić D, Antonijević B, Buha A, Bulat P, Pavlović Z, Matović V. Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2017;68(1):38-45.
doi:10.1515/aiht-2017-68-2919 .
Bulat, Zorica, Đukić-Ćosić, Danijela, Antonijević, Biljana, Buha, Aleksandra, Bulat, Petar, Pavlović, Zoran, Matović, Vesna, "Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 68, no. 1 (2017):38-45,
https://doi.org/10.1515/aiht-2017-68-2919 . .
