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dc.creatorMirjanić-Azarić, Bosa
dc.creatorAvram, Sanja
dc.creatorStojaković-Jelisavac, Tanja
dc.creatorStojanović, Darja
dc.creatorPetković, Mira
dc.creatorBogavac-Stanojević, Nataša
dc.creatorIgnjatović, Svetlana
dc.creatorStojanov, Marina
dc.date.accessioned2019-09-02T12:02:32Z
dc.date.available2019-09-02T12:02:32Z
dc.date.issued2017
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3008
dc.description.abstractBackground: The aim of this study was to determine the reference values for thyrotropin (TSH), thyroid hormones (total and free thyroxine, T4 and fT4; total and free triiodothyronine, T3 and fT3), thyroglobulin (Tg) and thyroid antibodies (thyroid peroxidase, TPOAb and thyroglobulin antibody, TgAb) in the population of the Republic of Srpska. Methods: A total of 250 euthyroid subjects were enrolled in this study. A direct method for choosing reference subjects was used to establish reference intervals. The hormones and thyroid antibodies were measured by an electrochemiluminescence immunoassay method (ECLIA, Roche Diagnostics, Mannheim, Germany). We calculated the re f erence intervals by MedCalc, version 12.1.4.0 (MedCalc software, Belgium) as recommended by the IFCC (CLSI C28-A3). Results: Using guidelines recommended by the National Academy of Clinical Biochemistry (NACB) and based on standard statistical approaches, the reference intervals derived for TSH, fT4, T4, fT3, T3 were 0.75-5.32 mIU/L, 12.29-20.03 pmol/L, 73.49-126,30 nmol/L, 4.11-6.32 pmol/L, 1.15-2.32 nmol/L and for Tg, TPOAb, TgAb were 3.63-26.00 mu g/L, lt 18.02 mIU/L, lt 98.00 mIU/L, respe ctively. We found a significant difference (p lt 0.05) in TSH and fT3 values between different age groups as well as in T4, fT4 and fT3 values between ge nder groups. Conclusions: The established reference values for the population of the Republic of Srpska were significantly different from the values recommended by the manufacturer of reagents (Roche Diagnostics). Our results showed that a laboratory needs to establish its own reference values in order to set up a proper diagnosis, as well as to treat patients successfully.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.titleDirect Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpskaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојанов, Марина; Богавац-Станојевић, Наташа; Игњатовић, Светлана; Мирјанић-Aзарић, Боса; Aврам, Сања; Петковић, Мира; Стојановић, Дарја; Стојаковић-Јелисавац, Тања;
dc.citation.volume36
dc.citation.issue2
dc.citation.spage137
dc.citation.epage144
dc.citation.other36(2): 137-144
dc.citation.rankM23
dc.identifier.wos000399907200005
dc.identifier.doi10.1515/jomb-2017-0008
dc.identifier.pmid28680357
dc.identifier.scopus2-s2.0-85018980517
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1615/3006.pdf
dc.identifier.rcubconv_3834
dc.type.versionpublishedVersion


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